{"doi":"10.1016/j.clim.2010.12.020","title":"Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis","abstract":null,"journal":"Clinical Immunology","year":2011,"id":620380,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1601523,"name":"Allyson Sholl","orcid":null,"position":1,"is_corresponding":false},{"id":1601524,"name":"Hwu dau rw Chen","orcid":null,"position":2,"is_corresponding":false},{"id":1601525,"name":"Connie Gard","orcid":null,"position":3,"is_corresponding":false},{"id":270445,"name":"David A. Hildeman","orcid":"0000-0002-0421-8483","position":4,"is_corresponding":false},{"id":505193,"name":"Ramireddy Bommireddy","orcid":"0000-0001-7367-3159","position":5,"is_corresponding":false},{"id":930269,"name":"Thomas Doetschman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis","abstract":"Calcineurin (CN) is a phosphatase that activates nuclear factor of activated T cells (NFAT). While the CN inhibitors cyclosporine A (CsA) and tacrolimus (FK506) can prevent graft rejection, they also cause inflammatory diseases. We investigated the role of calcineurin using mice deficient in the CN catalytic subunit Aβ (CNAβ). Cnab(-/-) mice exhibit defective thymocyte maturation, splenomegaly and hepatomegaly. Further, as Cnab(-/-) mice age, they exhibit spontaneous T-cell activation and enhanced production of proinflammatory cytokines (IL-4, IL-6, and IFNγ). FOXP3(+) T(reg) cells were significantly decreased in Cnab(-/-) mice likely contributing to increased T-cell activation. Interestingly, we found that CNAβ is critical for promotion of BCL-2 expression in FOXP3(+) T(reg) and for permitting TGFβ signaling, as TGFβ induces FOXP3 in control but not in Cnab(-/-) T-cells. Together, these data suggest that CNAβ is important for the production and maintenance of T(reg) cells and to ensure mature T-cell quiescence.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21256088","pmcid":"PMC3056286","openalex_id":"https://openalex.org/W2025218024","authors":[],"funders":[{"funder_name":"NIH","grant_id":"AI067903","title":null},{"funder_name":"NIH","grant_id":"U01CA084291","title":null},{"funder_name":"ACS","grant_id":"IRG7400128","title":null},{"funder_name":"NCI-CCSG","grant_id":"CA 023074","title":null},{"funder_name":"NCI-Lymphoma SPORE","grant_id":"P50CA3080501A1","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI067903","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI057753","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA023074","title":null}],"total_grants":8,"fwci":0.1217,"citation_percentile":0.49126067,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2021,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1521661610008120?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1521661610008120?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.clim.2010.12.020","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21256088","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3056286","host_type":"repository"}],"fields_of_study":["Signaling Pathways in Disease","Immune Cell Function and Interaction","NF-κB Signaling Pathways"],"mesh_terms":["Animals","Hepatomegaly","Homeostasis","Lymphocyte Activation","Mice, Mutant Strains","Splenomegaly","Signal Transduction","Cytokines","Transforming Growth Factor beta","Proto-Oncogene Proteins c-bcl-2","Calcineurin","T-Lymphocytes, Regulatory","Mice","Forkhead Transcription Factors"],"keywords":["NFAT","Calcineurin","FOXP3","T cell","Proinflammatory cytokine","Regulatory T cell","Cell biology","Chemistry","Tacrolimus","IL-2 receptor","Biology","Immunology","Transplantation","Inflammation","Immune system","Internal medicine","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T10:54:29.480473Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}