{"doi":"10.1016/j.clicom.2024.02.002","title":"Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis","abstract":"This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7%) were observed in 19% of untreated cases. Post-treatment, mean HLA-DR+ T cells decreased from 5.1 to 2.9 (P < 0.001), and serum neopterin levels declined from 19.3 to 9.1 nmol/L (P < 0.0001). A positive correlation between serum neopterin and HLA-DR T cell percentage was observed (r = 0.39, P = 0.01). Intravenous steroid treatment exhibited a 47.4% improvement in HLA-DR+ T cells and a 50.5% reduction in serum neopterin levels, in contrast to 14.8% and 34.1% in the oral steroid group. In conclusion, treatment, particularly with IV steroids, significantly improved HLA-DR+ T cells percentage and neopterin levels. A correlation between HLA-DR+ T cells percentage and serum neopterin was noted in untreated JDM patients.","journal":"Clinical Immunology Communications","year":2024,"id":476371,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9656,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1313904,"name":"Madeline Schutt","orcid":null,"position":1,"is_corresponding":false},{"id":461793,"name":"Gabrielle Morgan","orcid":"0000-0002-4058-7112","position":2,"is_corresponding":false},{"id":1113090,"name":"Ameera Bukhari","orcid":null,"position":3,"is_corresponding":false},{"id":1313905,"name":"Nicolas Bensen","orcid":null,"position":4,"is_corresponding":false},{"id":974206,"name":"Aaruni Khanolkar","orcid":null,"position":5,"is_corresponding":false},{"id":461792,"name":"Lauren M. Pachman","orcid":"0000-0001-8117-574X","position":6,"is_corresponding":false},{"id":662426,"name":"Amer Khojah","orcid":"0000-0003-3357-4863","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:06:25.428435Z","pmid":"38962376","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}