{"doi":"10.1016/j.clae.2025.102480","title":"Predicting contact lens discomfort from meibomian gland morphology and function","abstract":null,"journal":"Contact Lens and Anterior Eye","year":2025,"id":655067,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1709819,"name":"Eric B Papas","orcid":null,"position":1,"is_corresponding":false},{"id":1709822,"name":"Fiona Stapleton","orcid":null,"position":2,"is_corresponding":false},{"id":1709825,"name":"Waleed M. Alghamdi","orcid":null,"position":3,"is_corresponding":false},{"id":1709826,"name":"Amy Ruan","orcid":null,"position":4,"is_corresponding":false},{"id":1709827,"name":"Karuna Darvesh","orcid":null,"position":5,"is_corresponding":false},{"id":1709828,"name":"Lucy Nguyen","orcid":null,"position":6,"is_corresponding":false},{"id":1709829,"name":"Jacqueline Tan","orcid":null,"position":7,"is_corresponding":false},{"id":735358,"name":"Fatima Iqbal","orcid":"0000-0001-5368-8919","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Predicting contact lens discomfort from meibomian gland morphology and function","abstract":"<h4>Purpose</h4>To develop and validate a model to predict contact lens discomfort (CLD) using features of the meibomian glands (MG).<h4>Methods</h4>This study consisted of three parts: (i) 50 meibography images from contact lens wearers and non-wearers were assessed to distinguish features of interest between the groups to develop an automated algorithm which was tested on 154 images from CLD participants (ii) A multivariable model was constructed with a separate population of 84 lens wearers using imaging features and ocular surface signs to predict Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) score (iii) The model was validated on two independent sets of images using Bland-Altman comparisons between actual and predicted CLDEQ-8 scores.<h4>Results</h4>Part I: Intergland distance and width of the gland at the lid margin, centre and distal end were identified as features distinguishing between lens wearers and non-wearers. Part II: In univariate analysis, CLDEQ-8 scores were negatively associated with gland width at the lid margin (r = -0.52, p = 0.01) and lipid layer thickness (r = -0.40, p < 0.05) and positively associated with tear break-up time (r = 0.51, p < 0.001), MG expressibility (r = 0.35, p = 0.01), and intergland distance at the lid margin (r = 0.73, p = 0.02). The multivariable regression model accounted for 68 % (R<sup>2</sup> = 0.68, p < 0.05) of the variance in CLDEQ-8 scores. Part III: The mean difference (bias) between the predicted and actual CLDEQ-8 score was -0.1 with limits of agreement of ± 2.8 units.<h4>Conclusion</h4>Morphometric features of MG can predict CLDEQ-8 score in lens wearers with reasonable accuracy. This approach may be a suitable screening tool in early detection and to understand the natural history of CLD.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40750454","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.contactlensjournal.com/article/S1367-0484(25)00114-6/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1367048425001146?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1367048425001146?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Meibomian Glands","Tears","Humans","Dry Eye Syndromes","Contact Lenses","Contact Lenses, Hydrophilic","Algorithms","Adult","Middle Aged","Female","Male","Young Adult","Surveys and Questionnaires","Meibomian Gland Dysfunction"],"keywords":["Symptoms","Meibography","Meibomian Glands","Contact Lens Discomfort","Eyelid Margin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T09:31:24.492276Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}