{"doi":"10.1016/j.cjco.2024.01.006","title":"Early Effects of the COVID-19 Pandemic on Patients in a Virtual Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry","abstract":"The COVID-19 pandemic effects among patients with history of spontaneous coronary artery dissection (SCAD), a cause of acute coronary syndrome associated with emotional and physical stress, are unknown. For this cross-sectional cohort study, participants of the Mayo Clinic “Virtual” Multicenter SCAD Registry were surveyed about the COVID-19 pandemic. Among 1352 participants, 727(53.8%) completed surveys between 6/2/2021-9/29/2021. The majority(96.7%) of respondents were female with mean age of 54.9+9.4 years. At time of survey, which was early in the pandemic, 91(12.6%) respondents reported prior COVID-19 symptoms, with <1% experiencing hospitalization(N=4) or cardiac complications(N=6). Fourteen percent had > moderate anxiety symptoms by GAD-7 and 11.8% had > moderate depressive symptoms by PHQ-9. Higher stress on the Likert scale correlated with pandemic-related reduction in work hours/pay/unemployment(p=0.013), remote work/change of job(p<0.001), and loss of insurance/medical coverage(p=0.025). Higher anxiety on the Likert scale correlated with pandemic-related remote work/change of job(p=0.007) and loss of insurance/medical coverage(p=0.008). Since the start of the pandemic, 54% of respondents reported at least monthly chest pain. Chest pain and COVID symptoms were each associated with higher GAD-7 and PHQ-9 scores. Early in the pandemic, COVID-19 symptoms, hospitalization and cardiac complications were uncommon among SCAD patients. Burden of anxiety and depressive symptoms was minimal-mild, similar to prior reports. Likert scale measures of stress and anxiety were higher among persons with work/pay reduction/unemployment, remote/change of job and loss of insurance/medical coverage. Over half of respondents reported chest pain, which correlated with depressive and anxiety symptoms, highlighting an overarching clinical need.","journal":"CJC Open","year":2024,"id":462633,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5285,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":474867,"name":"Sharonne N. Hayes","orcid":"0000-0003-3129-362X","position":1,"is_corresponding":false},{"id":972954,"name":"Patricia J.M. Best","orcid":"0000-0002-7024-7186","position":2,"is_corresponding":false},{"id":355743,"name":"Rajiv Gulati","orcid":"0000-0002-2713-0433","position":3,"is_corresponding":false},{"id":980269,"name":"Benjamin R. Gochanour","orcid":null,"position":4,"is_corresponding":false},{"id":474868,"name":"Marysia S. Tweet","orcid":"0000-0002-1469-0554","position":5,"is_corresponding":false},{"id":771341,"name":"Yeonsoo Sara Lee","orcid":"0000-0001-9769-806X","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:04:24.680035Z","pmid":"38846446","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}