{"doi":"10.1016/j.cjca.2022.03.018","title":"Outcomes Following Patent Foramen Ovale Percutaneous Closure According to the Delay From Last Ischemic Event","abstract":null,"journal":"Canadian Journal of Cardiology","year":2022,"id":672845,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1758022,"name":"Jules Mesnier","orcid":null,"position":1,"is_corresponding":false},{"id":310750,"name":"Michel Zeitouni","orcid":"0000-0001-9562-3128","position":2,"is_corresponding":false},{"id":1758023,"name":"Marie Hauguel-Moreau","orcid":null,"position":3,"is_corresponding":false},{"id":1026769,"name":"Johanne Silvain","orcid":"0000-0002-1901-2808","position":4,"is_corresponding":false},{"id":1758024,"name":"Christine Houde","orcid":null,"position":5,"is_corresponding":false},{"id":1758025,"name":"Alberto Alperi","orcid":null,"position":6,"is_corresponding":false},{"id":1758026,"name":"Vassili Panagides","orcid":null,"position":7,"is_corresponding":false},{"id":50050,"name":"Jean-Philippe Collet","orcid":null,"position":8,"is_corresponding":false},{"id":1758027,"name":"Thomas Wallet","orcid":null,"position":9,"is_corresponding":false},{"id":1758028,"name":"Stéphanie Rouanet","orcid":null,"position":10,"is_corresponding":false},{"id":1015913,"name":"Nadjib Hammoudi","orcid":"0000-0003-2085-8525","position":11,"is_corresponding":false},{"id":1610784,"name":"Josep Rodés-Cabau","orcid":null,"position":12,"is_corresponding":false},{"id":2021,"name":"Gilles Montalescot","orcid":"0000-0003-0824-6809","position":13,"is_corresponding":false},{"id":870992,"name":"Paul Guedeney","orcid":"0000-0002-2012-4137","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Outcomes Following Patent Foramen Ovale Percutaneous Closure According to the Delay From Last Ischemic Event","abstract":"<h4>Background</h4>Randomised controlled trials evaluating percutaneous closure of patent foramen ovale (PFO) have included only patients with a recent embolic event. We aimed to evaluate outcomes after percutaneous PFO closure according to the delay from the last embolic episode.<h4>Methods</h4>This international ambispective cohort included consecutive patients from 2 centres in France and Canada undergoing PFO closure for secondary prevention of a paradoxical embolic event. The primary end point was the composite of stroke or transient ischemic attack (TIA). A logistic regression model was used to evaluate determinants of late PFO closure procedures.<h4>Results</h4>A total of 1179 patients (mean age 49 ± 12.7 years; 44.4% female) underwent PFO closure from 2001 to 2021. The median delay from last embolic event to procedure was 6.0 (interquartile range 3.4-11.2) months. The determinants of late PFO closure procedure were the centre (France vs Canada; adjusted odds ratio [aOR] 1.65, 95% confidence interval [CI] 1.25-2.19), year of procedure (since 2018 vs before 2018; aOR 1.43, 95% CI 1.08-1.90), female sex (aOR 1.63, 95% CI 1.28-2.07), and lower risk of paradoxical embolism score (aOR 1.10, 95% CI 1.03-1.19). After a median follow-up of 2.61 (1.13-7.25) years, the incidence rate of first stroke or TIA did not differ between early and late PFO procedures, with 0.51 vs 0.29 events per 100 patient-years, respectively (incidence rate ratio 1.74, 95% CI 0.66-5.08; P = 0.24), and the timing of PFO closure was not associated with the occurrence of stroke or TIA in univariate analysis (hazard ratio 0.54, 95% CI 0.22-1.34) for late vs early closure).<h4>Conclusions</h4>This analysis provides indirect evidence that the delay from the last ischemic event does not affect outcomes after PFO closure for secondary prevention.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35367571","pmcid":null,"openalex_id":"https://openalex.org/W4220877727","authors":[],"funders":[],"total_grants":0,"fwci":1.3607,"citation_percentile":0.80975027,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0828282X22002148?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0828282X22002148?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cjca.2022.03.018","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35367571","host_type":"repository"},{"url":"https://hal.science/hal-04002261","host_type":"repository"}],"fields_of_study":["Cardiovascular and Diving-Related Complications","Aortic Disease and Treatment Approaches","Atrial Fibrillation Management and Outcomes"],"mesh_terms":["Adult","Aged","Ischemic Attack, Transient","Embolism","Female","Humans","Male","Middle Aged","Recurrence","Treatment Outcome","Embolism, Paradoxical","Stroke","Foramen Ovale, Patent","Secondary Prevention","Septal Occluder Device"],"keywords":["Medicine","Patent foramen ovale","Paradoxical embolism","Interquartile range","Confidence interval","Percutaneous","Odds ratio","Stroke (engine)","Incidence (geometry)","Cohort","Internal medicine","Rate ratio","Surgery","Cardiology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T11:18:14.763402Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}