{"doi":"10.1016/j.chom.2025.11.002","title":"Environmental and maternal imprints on infant gut metabolic development","abstract":"Early life is a critical period for immune and metabolic development, but these patterns remain underexplored in populations from low- and middle-income countries. Here, we profile the microbiome and metabolome of 55 Bangladeshi mother-infant dyads over the first 6 months of life. Importantly, we observe an increase in microbially derived bile amidates and N-acyl lipids with age in conjunction with reads matching the bile salt hydrolase/transferase (bsh) gene. Although microbial source tracking confirms maternal fecal seeding, a substantial environmental contribution is also highlighted. Differences in infant fecal metabolic profiles are associated with delivery mode, maternal milk composition, household assets, and household-level water treatment. Cesarean section (C-section) delivery and untreated drinking water are linked to transient metabolic differences, including increases in bile amidates, N-acyl lipids, and other host-microbe co-metabolic products, including acylcarnitines. Multi-omics analysis reveals specific microbial-metabolite relationships, highlighting how early environmental and maternal living circumstances influence gut metabolic development through the microbiome.","journal":"Cell Host & Microbe","year":2025,"id":515035,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9478,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255421,"name":"Celeste Allaband","orcid":"0000-0003-1832-4858","position":1,"is_corresponding":false},{"id":323404,"name":"Jennifer C. Onuora","orcid":"0000-0002-2507-0529","position":2,"is_corresponding":false},{"id":413874,"name":"Daniela S. Perry","orcid":"0000-0001-6870-1194","position":3,"is_corresponding":false},{"id":363451,"name":"Simone Zuffa","orcid":"0000-0001-7237-3402","position":4,"is_corresponding":false},{"id":244709,"name":"Lucas Patel","orcid":"0000-0001-8607-2782","position":5,"is_corresponding":false},{"id":1235036,"name":"Vincent Charron‐Lamoureux","orcid":"0000-0001-9440-7036","position":6,"is_corresponding":false},{"id":1199348,"name":"Ipsita Mohanty","orcid":"0000-0001-5311-6443","position":7,"is_corresponding":false},{"id":1129497,"name":"Kristija Sejane","orcid":"0009-0004-9643-0458","position":8,"is_corresponding":false},{"id":1363786,"name":"Abubaker Patan","orcid":"0000-0003-1415-7829","position":9,"is_corresponding":false},{"id":1378519,"name":"Abdullah Al Mahmud","orcid":"0000-0003-4110-7552","position":10,"is_corresponding":false},{"id":52795,"name":"Tahmeed Ahmed","orcid":"0000-0002-4607-7439","position":11,"is_corresponding":false},{"id":421867,"name":"Diego G. Bassani","orcid":"0000-0001-6704-3820","position":12,"is_corresponding":false},{"id":1261211,"name":"Antonio González-Torres","orcid":"0000-0001-5427-0637","position":13,"is_corresponding":false},{"id":261694,"name":"Davidson H. Hamer","orcid":"0000-0002-4700-1495","position":14,"is_corresponding":false},{"id":289251,"name":"Rashidul Haque","orcid":"0000-0001-5100-136X","position":15,"is_corresponding":false},{"id":259188,"name":"Benjamin Ho","orcid":"0000-0002-9506-3738","position":16,"is_corresponding":false},{"id":1239760,"name":"Md. Iqbal Hossain","orcid":"0000-0002-0184-7153","position":17,"is_corresponding":false},{"id":1378520,"name":"Mohammad Shahidul Islam","orcid":"0000-0002-8799-7784","position":18,"is_corresponding":false},{"id":3535,"name":"Daniel McDonald","orcid":"0000-0003-0876-9060","position":19,"is_corresponding":false},{"id":1378521,"name":"Lisa G. Pell","orcid":"0000-0001-5116-9998","position":20,"is_corresponding":false},{"id":1378522,"name":"Huma Qamar","orcid":"0000-0002-5646-8548","position":21,"is_corresponding":false},{"id":959409,"name":"Daniel Roth","orcid":"0000-0001-7742-0925","position":22,"is_corresponding":false},{"id":227070,"name":"Samir K. Saha","orcid":"0000-0003-3820-0748","position":23,"is_corresponding":false},{"id":1379083,"name":"Prakesh S Shah","orcid":null,"position":24,"is_corresponding":false},{"id":1379084,"name":"Md Muniruzzaman Siddiqui","orcid":null,"position":25,"is_corresponding":false},{"id":467702,"name":"Shafiqul Alam Sarker","orcid":"0000-0002-5566-2322","position":26,"is_corresponding":false},{"id":1378523,"name":"Shamima Sultana","orcid":"0000-0001-7950-628X","position":27,"is_corresponding":false},{"id":563718,"name":"Sydney P. Thomas","orcid":"0000-0001-8261-1195","position":28,"is_corresponding":false},{"id":603508,"name":"Lindsey A. Burnett","orcid":"0000-0002-6430-4498","position":29,"is_corresponding":false},{"id":465666,"name":"Shirley M. Tsunoda","orcid":"0000-0002-3974-8038","position":30,"is_corresponding":false},{"id":240567,"name":"Lars Bode","orcid":"0000-0002-9914-9571","position":31,"is_corresponding":false},{"id":3553,"name":"Pieter C. 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