{"doi":"10.1016/j.chom.2025.06.006","title":"Immune profiling in subclinical secondary dengue-infected cases reveals adaptive immune signatures correlated to protection from severe dengue","abstract":"Development of strategies to prevent severe dengue has been challenging, partly by our incomplete understanding of a protective immune response after dengue virus (DENV) infection. To define adaptive immune signatures associated with protection from hospitalized dengue, we performed in-depth single-cell immunoprofiling and quantified DENV-specific T cells in subclinical or hospitalized dengue-infected children. Individuals with subclinical infection exhibit clonally expanded CD4 + TEMRA cells, increased frequency of DENV-specific CD4 + T cells, and demonstrate a gene expression signature of increased Treg functionality. Across all T cell subsets, subclinical cases upregulated a type I IFN response gene signature. In contrast, expanding CD8 + EM cells from hospitalized patients express more inhibitory markers and fewer cytotoxic proteins. In addition, hospitalized dengue is characterized by high frequencies and clonally expanded immunoglobulin G (Ig)G1-expressing plasmablasts. These findings identify candidate correlates of protection and support a rationale for T cell-directed interventions for dengue disease.","journal":"Cell Host & Microbe","year":2025,"id":511580,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":844012,"name":"Valentina Libri","orcid":"0000-0002-2080-1089","position":1,"is_corresponding":false},{"id":1294024,"name":"Emanuele Gioacchino","orcid":"0000-0002-2787-6286","position":2,"is_corresponding":false},{"id":1352224,"name":"Sébastien Mella","orcid":"0000-0002-8679-5718","position":3,"is_corresponding":false},{"id":959231,"name":"Sotheary Sann","orcid":null,"position":4,"is_corresponding":false},{"id":958867,"name":"Sopheak Sorn","orcid":"0000-0001-7376-1167","position":5,"is_corresponding":false},{"id":959232,"name":"Sreymom Ken","orcid":null,"position":6,"is_corresponding":false},{"id":1370338,"name":"Valérie Seffer","orcid":null,"position":7,"is_corresponding":false},{"id":1370339,"name":"Nisa Ya","orcid":null,"position":8,"is_corresponding":false},{"id":1274254,"name":"Leangyi Heng","orcid":null,"position":9,"is_corresponding":false},{"id":1276042,"name":"Chantana Yay","orcid":null,"position":10,"is_corresponding":false},{"id":628654,"name":"Anavaj Sakuntabhai","orcid":"0000-0001-9099-6937","position":11,"is_corresponding":false},{"id":628653,"name":"Sowath Ly","orcid":"0000-0003-0959-5445","position":12,"is_corresponding":false},{"id":475226,"name":"Philippe Dussart","orcid":"0000-0002-1931-3037","position":13,"is_corresponding":false},{"id":552660,"name":"Veasna Duong","orcid":"0000-0003-0353-1678","position":14,"is_corresponding":false},{"id":844011,"name":"Milena Hasan","orcid":"0000-0002-0879-7099","position":15,"is_corresponding":false},{"id":628655,"name":"Tineke Cantaert","orcid":"0000-0002-8911-1502","position":16,"is_corresponding":false},{"id":1369603,"name":"Giorgio Gonnella","orcid":"0000-0003-3900-5397","position":0,"is_corresponding":true}],"reference_count":114,"raw_metadata":null,"created_at":"2026-07-19T02:47:55.918021Z","pmid":"40580952","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}