{"doi":"10.1016/j.chom.2024.10.002","title":"Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme","abstract":"Gut microbial catechol dehydroxylases are a largely uncharacterized family of metalloenzymes that potentially impact human health by metabolizing dietary polyphenols. Here, we use metatranscriptomics (MTX) to identify highly transcribed catechol-dehydroxylase-encoding genes in human gut microbiomes. We discover a prevalent, previously uncharacterized catechol dehydroxylase (Gp Hcdh) from Gordonibacter pamelaeae that dehydroxylates hydrocaffeic acid (HCA), an anti-inflammatory gut microbial metabolite derived from plant-based foods. Further analyses suggest that the activity of Gp Hcdh may reduce anti-inflammatory benefits of polyphenol-rich foods. Together, these results show the utility of combining MTX analysis and biochemical characterization for gut microbial enzyme discovery and reveal a potential link between host inflammation and a specific polyphenol-metabolizing gut microbial enzyme.","journal":"Cell Host & Microbe","year":2024,"id":420521,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1211951,"name":"Chi Hieu Le","orcid":"0000-0002-5168-2297","position":1,"is_corresponding":false},{"id":104563,"name":"Raaj S. Mehta","orcid":null,"position":2,"is_corresponding":false},{"id":634889,"name":"Xueyang Dong","orcid":"0000-0003-2186-1726","position":3,"is_corresponding":false},{"id":1010063,"name":"Lindsey M. Pieper","orcid":"0000-0003-3022-5721","position":4,"is_corresponding":false},{"id":869261,"name":"Lorenzo Ramirez","orcid":null,"position":5,"is_corresponding":false},{"id":256564,"name":"Margaret Alexander","orcid":"0000-0003-2972-7521","position":6,"is_corresponding":false},{"id":301872,"name":"Sina Kiamehr","orcid":"0000-0002-4917-9393","position":7,"is_corresponding":false},{"id":36356,"name":"Peter J. Turnbaugh","orcid":"0000-0002-0888-2875","position":8,"is_corresponding":false},{"id":493,"name":"Curtis Huttenhower","orcid":"0000-0002-1110-0096","position":9,"is_corresponding":false},{"id":41038,"name":"Andrew T. Chan","orcid":"0000-0001-7284-6767","position":10,"is_corresponding":false},{"id":234900,"name":"Emily P. Balskus","orcid":"0000-0001-5985-5714","position":11,"is_corresponding":false},{"id":899652,"name":"Minwoo Bae","orcid":"0000-0002-0313-5520","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T01:57:31.041511Z","pmid":"39471822","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}