{"doi":"10.1016/j.chom.2024.05.008","title":"Epithelial hypoxia maintains colonization resistance against Candida albicans","abstract":"Antibiotic treatment promotes the outgrowth of intestinal Candida albicans, but the mechanisms driving this fungal bloom remain incompletely understood. We identify oxygen as a resource required for post-antibiotic C. albicans expansion. C. albicans depleted simple sugars in the ceca of gnotobiotic mice but required oxygen to grow on these resources in vitro, pointing to anaerobiosis as a potential factor limiting growth in the gut. Clostridia species limit oxygen availability in the large intestine by producing butyrate, which activates peroxisome proliferator-activated receptor gamma (PPAR-γ) signaling to maintain epithelial hypoxia. Streptomycin treatment depleted Clostridia-derived butyrate to increase epithelial oxygenation, but the PPAR-γ agonist 5-aminosalicylic acid (5-ASA) functionally replaced Clostridia species to restore epithelial hypoxia and colonization resistance against C. albicans. Additionally, probiotic Escherichia coli required oxygen respiration to prevent a post-antibiotic bloom of C. albicans, further supporting the role of oxygen in colonization resistance. We conclude that limited access to oxygen maintains colonization resistance against C. albicans.","journal":"Cell Host & Microbe","year":2024,"id":418403,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9462,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":863179,"name":"Derek J. Bays","orcid":"0000-0003-0264-5569","position":1,"is_corresponding":false},{"id":630395,"name":"Connor R. Tiffany","orcid":"0000-0001-8188-7720","position":2,"is_corresponding":false},{"id":1175405,"name":"Mariela A. F. Gonzalez","orcid":null,"position":3,"is_corresponding":false},{"id":1175406,"name":"Eli J. Bejarano","orcid":null,"position":4,"is_corresponding":false},{"id":1060496,"name":"Thaynara Parente de Carvalho","orcid":"0000-0002-7158-8249","position":5,"is_corresponding":false},{"id":570782,"name":"Zheng Luo","orcid":"0000-0001-5168-4674","position":6,"is_corresponding":false},{"id":1014301,"name":"Hugo L. P. Masson","orcid":"0009-0000-4156-8549","position":7,"is_corresponding":false},{"id":630398,"name":"Henry Nguyen","orcid":"0000-0002-6737-1485","position":8,"is_corresponding":false},{"id":728915,"name":"Renato L. Santos","orcid":"0000-0002-4830-0470","position":9,"is_corresponding":false},{"id":881980,"name":"Krystle L. Reagan","orcid":"0000-0003-3426-6352","position":10,"is_corresponding":false},{"id":249633,"name":"George R. Thompson","orcid":"0000-0001-8518-5750","position":11,"is_corresponding":false},{"id":630400,"name":"Andreas J. Bäumler","orcid":"0000-0001-9152-7809","position":12,"is_corresponding":false},{"id":630397,"name":"Hannah P. Savage","orcid":"0000-0002-1057-7239","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T01:57:02.483590Z","pmid":"38838675","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}