{"doi":"10.1016/j.chom.2023.12.010","title":"Memory T cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant","abstract":"T cells are critical in mediating the early control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection. However, it remains unknown whether memory T cells can effectively cross-recognize new SARS-CoV-2 variants with a broad array of mutations, such as the emergent hypermutated BA.2.86 variant. Here, we report in two separate cohorts, including healthy controls and individuals with chronic lymphocytic leukemia, that SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by prior infection or vaccination demonstrate resilient immune recognition of BA.2.86. In both cohorts, we found largely preserved SARS-CoV-2 spike-specific CD4+ and CD8+ T cell magnitudes against mutated spike epitopes of BA.2.86. Functional analysis confirmed that both cytokine expression and proliferative capacity of SARS-CoV-2 spike-specific T cells to BA.2.86-mutated spike epitopes are similarly sustained. In summary, our findings indicate that memory CD4+ and CD8+ T cells continue to provide cell-mediated immune recognition to highly mutated emerging variants such as BA.2.86.","journal":"Cell Host & Microbe","year":2024,"id":419697,"datarank":1.2888868895236767,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.7393526426042296,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.7393526426042296,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":33,"citers_with_citation_signal":24,"citers_with_endowment":24,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":501133,"name":"Yu Gao","orcid":"0000-0002-4615-3614","position":1,"is_corresponding":false},{"id":1153026,"name":"Jinghua Wu","orcid":"0000-0002-8301-3995","position":2,"is_corresponding":false},{"id":1210413,"name":"Oriana Ribeiro","orcid":null,"position":3,"is_corresponding":false},{"id":104846,"name":"Puran Chen","orcid":"0000-0002-2890-0022","position":4,"is_corresponding":false},{"id":312380,"name":"Peter Bergman","orcid":"0000-0003-3306-3713","position":5,"is_corresponding":false},{"id":854504,"name":"Ola Blennow","orcid":"0000-0002-7167-7882","position":6,"is_corresponding":false},{"id":650096,"name":"Lotta Hansson","orcid":"0000-0001-6614-5737","position":7,"is_corresponding":false},{"id":620959,"name":"Stephan Mielke","orcid":"0000-0002-8325-9215","position":8,"is_corresponding":false},{"id":97899,"name":"Piotr Nowak","orcid":"0000-0003-2747-0734","position":9,"is_corresponding":false},{"id":654509,"name":"Jan Vesterbacka","orcid":null,"position":10,"is_corresponding":false},{"id":104839,"name":"Mira Akber","orcid":null,"position":11,"is_corresponding":false},{"id":854505,"name":"Gunnar Söderdahl","orcid":"0000-0002-4423-2458","position":12,"is_corresponding":false},{"id":855387,"name":"C.I. 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