{"doi":"10.1016/j.chom.2023.01.003","title":"Longitudinal comparison of the developing gut virome in infants and their mothers","abstract":"The human gut virome and its early life development are poorly understood. Prior studies have captured single-point assessments with the evolution of the infant virome remaining largely unexplored. We performed viral metagenomic sequencing on stool samples collected longitudinally from a cohort of 53 infants from age 2 weeks to 3 years (80.7 billion reads), and from their mothers (9.8 billion reads) to examine and compare viromes. The asymptomatic infant virome consisted of bacteriophages, nonhuman dietary/environmental viruses, and human-host viruses, predominantly picornaviruses. In contrast, human-host viruses were largely absent from the maternal virome. Previously undescribed, sequence-divergent vertebrate viruses were detected in the maternal but not infant virome. As infants aged, the phage component evolved to resemble the maternal virome, but by age 3, the human-host component remained dissimilar from the maternal virome. Thus, early life virome development is determined predominantly by dietary, infectious, and environmental factors rather than direct maternal acquisition.","journal":"Cell Host & Microbe","year":2023,"id":319718,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8805,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104236,"name":"Andrea Granados","orcid":"0000-0001-6759-0154","position":1,"is_corresponding":false},{"id":451780,"name":"Catherine Ley","orcid":"0000-0002-8424-7873","position":2,"is_corresponding":false},{"id":109291,"name":"Scot Federman","orcid":"0000-0001-8712-3131","position":3,"is_corresponding":false},{"id":109290,"name":"Doug Stryke","orcid":null,"position":4,"is_corresponding":false},{"id":252830,"name":"Yale Santos","orcid":null,"position":5,"is_corresponding":false},{"id":452393,"name":"Thomas D. Haggerty","orcid":null,"position":6,"is_corresponding":false},{"id":94490,"name":"Alicia Sotomayor-González","orcid":"0000-0002-8930-745X","position":7,"is_corresponding":false},{"id":94466,"name":"Venice Servellita","orcid":"0000-0002-1745-4012","position":8,"is_corresponding":false},{"id":19807,"name":"Ruth E. Ley","orcid":"0000-0002-9087-1672","position":9,"is_corresponding":false},{"id":231939,"name":"Julie Parsonnet","orcid":"0000-0001-7342-5366","position":10,"is_corresponding":false},{"id":92394,"name":"Charles Y. Chiu","orcid":"0000-0003-2915-2094","position":11,"is_corresponding":false},{"id":49758,"name":"William A. Walters","orcid":"0000-0003-1716-3984","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T01:07:17.361058Z","pmid":"36758519","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}