{"doi":"10.1016/j.chom.2021.12.007","title":"Anatomy promotes neutral coexistence of strains in the human skin microbiome","abstract":null,"journal":"Cell Host &amp; Microbe","year":2022,"id":611770,"datarank":0.7755725992557229,"base_score":5.170483995038151,"endowment":5.170483995038151,"self_citation_contribution":0.7755725992557229,"citation_network_contribution":0.0,"self_endowment_contribution":0.7755725992557229,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":175,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":807223,"name":"Anne C. Kuan","orcid":null,"position":1,"is_corresponding":false},{"id":806439,"name":"Ravalika Damerla","orcid":"0000-0003-3219-7365","position":2,"is_corresponding":false},{"id":806440,"name":"Alexandra J. Poret","orcid":"0000-0002-0723-987X","position":3,"is_corresponding":false},{"id":806441,"name":"Jacob S. Baker","orcid":"0000-0002-0249-5014","position":4,"is_corresponding":false},{"id":1574754,"name":"A. Delphine Tripp","orcid":null,"position":5,"is_corresponding":false},{"id":29035,"name":"Eric J. Alm","orcid":"0000-0001-8294-9364","position":6,"is_corresponding":false},{"id":806442,"name":"Tami D. Lieberman","orcid":"0000-0001-5430-3937","position":7,"is_corresponding":false},{"id":806438,"name":"Arolyn Conwill","orcid":"0000-0002-6052-0345","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Anatomy promotes neutral coexistence of strains in the human skin microbiome","abstract":"What enables strains of the same species to coexist in a microbiome? Here, we investigate whether host anatomy can explain strain co-residence of Cutibacterium acnes, the most abundant species on human skin. We reconstruct on-person evolution and migration using whole-genome sequencing of C. acnes colonies acquired from healthy subjects, including from individual skin pores, and find considerable spatial structure at the level of pores. Although lineages (sets of colonies separated by <100 mutations) with in vitro fitness differences coexist within centimeter-scale regions, each pore is dominated by a single lineage. Moreover, colonies from a pore typically have identical genomes. An absence of adaptive signatures suggests a genotype-independent source of low within-pore diversity. We therefore propose that pore anatomy imposes random single-cell bottlenecks; the resulting population fragmentation reduces competition and promotes coexistence. Our findings suggest that therapeutic interventions involving pore-dwelling species might focus on removing resident populations over optimizing probiotic fitness.","is_dataset_classified":null,"base_score":5.170483995038151,"endowment":5.170483995038151,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34995483","pmcid":"PMC8831475","openalex_id":"https://openalex.org/W4220718067","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"DP2 GM140922","title":null},{"funder_name":"National Institutes of Health","grant_id":"1DP2GM140922-01","title":"An Evolutionary Framework For Identifying Determinants Of Colonization In Human Microbiomes"}],"total_grants":2,"fwci":32.7412,"citation_percentile":0.9989554,"influential_citations":0,"citation_trend":[{"year":2021,"count":3},{"year":2022,"count":23},{"year":2023,"count":37},{"year":2024,"count":48},{"year":2025,"count":49},{"year":2026,"count":15}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.cell.com/article/S1931312821005783/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1931312821005783/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1931312821005783?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1931312821005783?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.chom.2021.12.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34995483","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8831475","host_type":"repository"},{"url":"https://doi.org/10.1101/2021.05.12.443817","host_type":""},{"url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/14/2021.05.12.443817.full.pdf","host_type":""},{"url":"https://dx.doi.org/10.1101/2021.05.12.443817","host_type":""},{"url":"https://hdl.handle.net/1721.1/147721","host_type":""}],"fields_of_study":["Dermatology and Skin Diseases","Gut microbiota and health","Acne and Rosacea Treatments and Effects","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Whole Genome Sequencing","Acne Vulgaris","Humans","Propionibacterium acnes","Skin","Microbiota"],"keywords":["Biology","Microbiome","Evolutionary biology","Population","Human microbiome","Genome","Fragmentation (computing)","Genetics","Ecology","Gene","Molecular evolution","Genomics","Bacterial Evolution","Skin Microbiome","Bacterial Genomics","Whole Genome Sequencing","Microbiota","Acne Vulgaris","Humans","Propionibacterium acnes","Skin"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.25661751","title":"Additional file 1 of Fast and accurate variant identification tool for sequencing-based studies","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.25661751.v1","title":"Additional file 1 of Fast and accurate variant identification tool for sequencing-based studies","publisher":"figshare","resource_type":"Text"},{"doi":"10.6084/m9.figshare.25661789","title":"Additional file 2 of Fast and accurate variant identification tool for sequencing-based studies","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.25661789.v1","title":"Additional file 2 of Fast and accurate variant identification tool for sequencing-based studies","publisher":"figshare","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"bioproject"},{"name":"gen"},{"name":"refseq"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T22:25:08.693577Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}