{"doi":"10.1016/j.chom.2021.12.002","title":"Enteric virome negatively affects seroconversion following oral rotavirus vaccination in a longitudinally sampled cohort of Ghanaian infants","abstract":"Rotavirus vaccines (RVVs) have substantially diminished mortality from severe rotavirus (RV) gastroenteritis but are significantly less effective in low- and middle-income countries (LMICs), limiting their life-saving potential. The etiology of RVV's diminished effectiveness remains incompletely understood, but the enteric microbiota has been implicated in modulating immunity to RVVs. Here, we analyze the enteric microbiota in a longitudinal cohort of 122 Ghanaian infants, evaluated over the course of 3 Rotarix vaccinations between 6 and 15 weeks of age, to assess whether bacterial and viral populations are distinct between non-seroconverted and seroconverted infants. We identify bacterial taxa including Streptococcus and a poorly classified taxon in Enterobacteriaceae as positively correlating with seroconversion. In contrast, both bacteriophage diversity and detection of Enterovirus B and multiple novel cosaviruses are negatively associated with RVV seroconversion. These findings suggest that virome-RVV interference is an underappreciated cause of poor vaccine performance in LMICs.","journal":"Cell Host & Microbe","year":2021,"id":156847,"datarank":0.5983476069846413,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":0.0,"self_endowment_contribution":0.5983476069846413,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":506058,"name":"George Armah","orcid":"0000-0001-6078-9953","position":1,"is_corresponding":false},{"id":662345,"name":"Francis E. Dennis","orcid":"0000-0003-2078-6955","position":2,"is_corresponding":false},{"id":413851,"name":"Leran Wang","orcid":"0009-0003-6928-9893","position":3,"is_corresponding":false},{"id":491706,"name":"Rachel Rodgers","orcid":"0000-0001-7787-0491","position":4,"is_corresponding":false},{"id":227337,"name":"Lindsay Droit","orcid":"0000-0002-5771-1490","position":5,"is_corresponding":false},{"id":298001,"name":"Megan T. Baldridge","orcid":"0000-0002-7030-6131","position":6,"is_corresponding":false},{"id":36382,"name":"Scott A. Handley","orcid":"0000-0002-2143-6570","position":7,"is_corresponding":false},{"id":662346,"name":"Vanessa Harris","orcid":"0000-0002-4881-5263","position":8,"is_corresponding":false},{"id":662344,"name":"Andrew HyoungJin Kim","orcid":"0000-0003-0971-6024","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:44:13.017332Z","pmid":"34932985","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}