{"doi":"10.1016/j.chom.2021.04.005","title":"A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection","abstract":"Coronaviruses have caused several human epidemics and pandemics including the ongoing coronavirus disease 2019 (COVID-19). Prophylactic vaccines and therapeutic antibodies have already shown striking effectiveness against COVID-19. Nevertheless, concerns remain about antigenic drift in SARS-CoV-2 as well as threats from other sarbecoviruses. Cross-neutralizing antibodies to SARS-related viruses provide opportunities to address such concerns. Here, we report on crystal structures of a cross-neutralizing antibody, CV38-142, in complex with the receptor-binding domains from SARS-CoV-2 and SARS-CoV. Recognition of the N343 glycosylation site and water-mediated interactions facilitate cross-reactivity of CV38-142 to SARS-related viruses, allowing the antibody to accommodate antigenic variation in these viruses. CV38-142 synergizes with other cross-neutralizing antibodies, notably COVA1-16, to enhance neutralization of SARS-CoV and SARS-CoV-2, including circulating variants of concern B.1.1.7 and B.1.351. Overall, this study provides valuable information for vaccine and therapeutic design to address current and future antigenic drift in SARS-CoV-2 and to protect against zoonotic SARS-related coronaviruses.","journal":"Cell Host & Microbe","year":2021,"id":153041,"datarank":0.6435689161722588,"base_score":4.290459441148391,"endowment":4.290459441148391,"self_citation_contribution":0.6435689161722588,"citation_network_contribution":0.0,"self_endowment_contribution":0.6435689161722588,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":105423,"name":"Meng Yuan","orcid":"0000-0001-9754-4503","position":1,"is_corresponding":false},{"id":108972,"name":"Deli Huang","orcid":"0000-0002-6989-639X","position":2,"is_corresponding":false},{"id":230740,"name":"Sandhya Bangaru","orcid":"0000-0001-7994-4693","position":3,"is_corresponding":false},{"id":108971,"name":"Fangzhu Zhao","orcid":"0000-0002-3172-1340","position":4,"is_corresponding":false},{"id":105426,"name":"Chang‐Chun D. Lee","orcid":"0000-0002-5470-2484","position":5,"is_corresponding":false},{"id":300949,"name":"Linghang Peng","orcid":"0000-0002-3600-2134","position":6,"is_corresponding":false},{"id":649569,"name":"Shawn Barman","orcid":"0000-0003-0008-2811","position":7,"is_corresponding":false},{"id":105425,"name":"Xueyong Zhu","orcid":"0000-0002-6021-3740","position":8,"is_corresponding":false},{"id":109546,"name":"David Nemazee","orcid":"0000-0002-4769-6311","position":9,"is_corresponding":false},{"id":108980,"name":"Dennis R. Burton","orcid":"0000-0001-6711-9864","position":10,"is_corresponding":false},{"id":240717,"name":"Marit J. van Gils","orcid":"0000-0003-3422-8161","position":11,"is_corresponding":false},{"id":240718,"name":"Rogier W. Sanders","orcid":"0000-0002-2324-8573","position":12,"is_corresponding":false},{"id":230481,"name":"Hans‐Christian Kornau","orcid":"0000-0003-4187-7549","position":13,"is_corresponding":false},{"id":230480,"name":"S. Momsen Reincke","orcid":"0000-0002-8132-3527","position":14,"is_corresponding":false},{"id":230505,"name":"Harald Prüß","orcid":"0000-0002-8283-7976","position":15,"is_corresponding":false},{"id":230479,"name":"Jakob Kreye","orcid":"0000-0003-2913-1015","position":16,"is_corresponding":false},{"id":105424,"name":"Nicholas C. Wu","orcid":"0000-0002-9078-6697","position":17,"is_corresponding":false},{"id":230082,"name":"Andrew B. Ward","orcid":"0000-0001-7153-3769","position":18,"is_corresponding":false},{"id":105430,"name":"Ian A. Wilson","orcid":"0000-0002-6469-2419","position":19,"is_corresponding":false},{"id":108970,"name":"Hejun Liu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":99,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:43:39.820288Z","pmid":"33894127","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}