{"doi":"10.1016/j.chemosphere.2019.124677","title":"Organic contaminants in human breast milk identified by non-targeted analysis","abstract":null,"journal":"Chemosphere","year":2020,"id":672793,"datarank":0.6261580904843456,"base_score":4.174387269895637,"endowment":4.174387269895637,"self_citation_contribution":0.6261580904843456,"citation_network_contribution":0.0,"self_endowment_contribution":0.6261580904843456,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":356988,"name":"Nathan G. Dodder","orcid":"0000-0001-5913-1767","position":1,"is_corresponding":false},{"id":457866,"name":"Penelope J.E. Quintana","orcid":null,"position":2,"is_corresponding":false},{"id":456463,"name":"Kayo Watanabe","orcid":"0000-0002-2404-0635","position":3,"is_corresponding":false},{"id":420796,"name":"Jae Kim","orcid":"0000-0001-6321-2594","position":4,"is_corresponding":false},{"id":334537,"name":"Melbourne F. Hovell","orcid":"0000-0001-7239-1627","position":5,"is_corresponding":false},{"id":901183,"name":"Christina D. Chambers","orcid":null,"position":6,"is_corresponding":false},{"id":356989,"name":"Eunha Hoh","orcid":"0000-0002-4075-040X","position":7,"is_corresponding":false},{"id":1757878,"name":"Cuong D. Tran","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Organic contaminants in human breast milk identified by non-targeted analysis","abstract":"Understanding the health implications of human exposure to mixtures of chemical contaminants is aided by analytical methods that can screen for a broad range of both expected and unexpected compounds. We performed a proof-of-concept analysis combining human breast milk, a biomonitoring matrix for determining contaminant exposure to mothers and infants, with a non-targeted method based on comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC/TOF-MS). A total of 172 presumably anthropogenic halogenated compounds and non-halogenated cyclic and aromatic compounds were tentatively identified in breast milk from San Diego, California through mass spectral database searches. Forty of the compounds were prioritized for confirmation based on halogenation or 100% frequency of detection, and the identities of 30 were verified using authentic standards. Thirty-four (85%) of the prioritized contaminants are not typically monitored in breast milk surveys, and 31 (77%) are regulated in at least one market worldwide, indicating breast milk may be a useful biomonitoring matrix for non-targeted analysis and the assessment of human exposure to future emerging or undiscovered contaminants.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31524616","pmcid":"PMC6832863","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Science Foundation","grant_id":"OCE-1313747","title":null},{"funder_name":"National Institute of Environmental Health Sciences","grant_id":"P01-ES021921","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"HHSN267200700021C","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"P01 ES021921","title":null},{"funder_name":"San Diego State University","grant_id":"","title":null}],"total_grants":5,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6832863","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0045653519319010?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0045653519319010?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Milk, Human","Humans","Organic Chemicals","Environmental Exposure","California","Female","Gas Chromatography-Mass Spectrometry","Halogenation","Biological Monitoring"],"keywords":["Organic contaminants","biomonitoring","Human Breast Milk","Gc×gc/tof-ms","Non-targeted Analysis"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T11:00:21.441455Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}