{"doi":"10.1016/j.cels.2017.09.015","title":"Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle","abstract":null,"journal":"Cell Systems","year":2017,"id":683147,"datarank":0.7814229229262133,"base_score":5.209486152841421,"endowment":5.209486152841421,"self_citation_contribution":0.7814229229262133,"citation_network_contribution":0.0,"self_endowment_contribution":0.7814229229262133,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":182,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1151065,"name":"Cere E. Poovey","orcid":null,"position":1,"is_corresponding":false},{"id":1350681,"name":"Ashley A. Privette","orcid":null,"position":2,"is_corresponding":false},{"id":63624,"name":"Gavin D. Grant","orcid":"0000-0002-8958-2056","position":3,"is_corresponding":false},{"id":1350682,"name":"Hui Yan Chao","orcid":null,"position":4,"is_corresponding":false},{"id":1784594,"name":"Jeanette G. Cook","orcid":null,"position":5,"is_corresponding":false},{"id":466075,"name":"Jeremy E. Purvis","orcid":"0000-0002-6963-0524","position":6,"is_corresponding":false},{"id":1784593,"name":"Hui Xiao Chao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle","abstract":"Although molecular mechanisms that prompt cell-cycle arrest in response to DNA damage have been elucidated, the systems-level properties of DNA damage checkpoints are not understood. Here, using time-lapse microscopy and simulations that model the cell cycle as a series of Poisson processes, we characterize DNA damage checkpoints in individual, asynchronously proliferating cells. We demonstrate that, within early G1 and G2, checkpoints are stringent: DNA damage triggers an abrupt, all-or-none cell-cycle arrest. The duration of this arrest correlates with the severity of DNA damage. After the cell passes commitment points within G1 and G2, checkpoint stringency is relaxed. By contrast, all of S phase is comparatively insensitive to DNA damage. This checkpoint is graded: instead of halting the cell cycle, increasing DNA damage leads to slower S phase progression. In sum, we show that a cell's response to DNA damage depends on its exact cell-cycle position and that checkpoints are phase-dependent, stringent or relaxed, and graded or all-or-none.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29102360","pmcid":"PMC5700845","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIH","grant_id":"R00-GM102372","title":null},{"funder_name":"NIH","grant_id":"R01-GM102413","title":null},{"funder_name":"NIH","grant_id":"R01-GM083024","title":null},{"funder_name":"NIH","grant_id":"T32CA009156","title":null},{"funder_name":"NIH","grant_id":"T32-GM067553","title":null},{"funder_name":"NIH","grant_id":"F30-CA213876","title":null},{"funder_name":"NCI NIH HHS","grant_id":"F30 CA213876","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM102413","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM083024","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"K99 GM102372","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA016086","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R00 GM102372","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM067553","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"DP2 HD091800","title":null},{"funder_name":"North Carolina University Cancer Research","grant_id":"","title":null},{"funder_name":"W. M. Keck Foundation","grant_id":"","title":null}],"total_grants":16,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S2405471217304362/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2405471217304362?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2405471217304362?httpAccept=text/plain","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5700845","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Cell Line","Humans","DNA Damage","Cell Proliferation","Cell Cycle Checkpoints"],"keywords":["DNA damage","Computational Modeling","Live-cell Imaging","Single-cell Dynamics","Cell-cycle Checkpoints"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T22:37:20.041723Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}