{"doi":"10.1016/j.celrep.2025.116848","title":"Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1","abstract":null,"journal":"Cell Reports","year":2026,"id":619029,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":693593,"name":"Ryan L. Kan","orcid":"0000-0003-1162-8365","position":1,"is_corresponding":false},{"id":1070753,"name":"Can Yilgor","orcid":"0009-0000-9214-4324","position":2,"is_corresponding":false},{"id":1003014,"name":"Elisa Fazzari","orcid":"0000-0001-5651-8587","position":3,"is_corresponding":false},{"id":581317,"name":"Patricia R. Nano","orcid":"0000-0002-5507-2656","position":4,"is_corresponding":false},{"id":1597311,"name":"Daria J. Azizad","orcid":null,"position":5,"is_corresponding":false},{"id":1597312,"name":"Heer Shinglot","orcid":null,"position":6,"is_corresponding":false},{"id":946938,"name":"Matthew Li","orcid":"0000-0003-1320-7134","position":7,"is_corresponding":false},{"id":1597313,"name":"Joyce Y. Ito","orcid":null,"position":8,"is_corresponding":false},{"id":862591,"name":"Christopher Tse","orcid":null,"position":9,"is_corresponding":false},{"id":1327971,"name":"Hong A. Tum","orcid":null,"position":10,"is_corresponding":false},{"id":1597314,"name":"Jessica Scholes","orcid":null,"position":11,"is_corresponding":false},{"id":1327509,"name":"Shivani Baisiwala","orcid":"0000-0001-5252-9940","position":12,"is_corresponding":false},{"id":1597315,"name":"Kunal S. Patel","orcid":null,"position":13,"is_corresponding":false},{"id":401464,"name":"David A. Nathanson","orcid":"0000-0002-4919-9159","position":14,"is_corresponding":false},{"id":104403,"name":"Aparna Bhaduri","orcid":"0000-0003-4625-6899","position":15,"is_corresponding":false},{"id":1327507,"name":"Weihong Ge","orcid":"0000-0003-2218-6291","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1","abstract":"Glioblastoma is the most aggressive and deadly form of brain cancer. Here, we leverage our human organoid tumor transplantation (HOTT) co-culture system to explore how extrinsic cues modulate glioblastoma cell types and behavior. HOTT recapitulates core features of major patient tumor cell types and key aspects of neural cell-enriched tumor microenvironment (nTME) gene programs. Our exploration of patient TME interactions preserved in HOTT highlights four receptor-ligand interactions of interest. We knock down all four of these genes in the HOTT microenvironment. We observe that knocking down nTME PTPRZ1, a receptor tyrosine phosphatase implicated in cancer cell migration, results in an increased fraction of mesenchymal cells, enrichment of epithelial-to-mesenchymal gene programs, and an elevated tumor microtube length in co-cultured primary patient tumors. This phenotype is not mediated by PTPRZ1's catalytic activity, suggesting a mechanism of tumor cell fate driven by nTME PTPRZ1, highlighting the strengths of the HOTT system.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41543935","pmcid":"PMC12950190","openalex_id":"https://openalex.org/W7124173955","authors":[],"funders":[{"funder_name":"American Cancer Society Inc","grant_id":"CSCC-Team-23-980262-01-CSCC","title":null},{"funder_name":"National Institutes of Health National Cancer Institute","grant_id":"P50CA211015","title":null},{"funder_name":"National Institutes of Health","grant_id":"T32GM145388","title":null},{"funder_name":"Uncle Kory Foundation","grant_id":"","title":null},{"funder_name":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles","grant_id":"","title":null},{"funder_name":"V Foundation","grant_id":"","title":null},{"funder_name":"Swim Across America","grant_id":"","title":null},{"funder_name":"Alfred P Sloan Foundation","grant_id":"","title":null},{"funder_name":"Sontag Foundation","grant_id":"","title":null},{"funder_name":"The Rose Hills Foundation","grant_id":"","title":null},{"funder_name":"University of California, Los Angeles","grant_id":"","title":null},{"funder_name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles","grant_id":"","title":null}],"total_grants":12,"fwci":41.7301,"citation_percentile":0.9981125,"influential_citations":0,"citation_trend":[{"year":2026,"count":8}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.1016/j.celrep.2025.116848","host_type":"journal"},{"url":"https://doi.org/10.1016/j.celrep.2025.116848","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124725016201?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124725016201?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41543935","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12950190/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12950190","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12950190?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cancer Cells and Metastasis","Glioma Diagnosis and Treatment","Cancer, Stress, Anesthesia, and Immune Response","Humans","Glioblastoma","Tumor Microenvironment","Organoids","Receptor-Like Protein Tyrosine Phosphatases, Class 5","Brain Neoplasms","Coculture Techniques","Cell Line, Tumor","Animals","Epithelial-Mesenchymal Transition","Neoplasm Transplantation","Cell Communication"],"mesh_terms":["Animals","Brain Neoplasms","Cell Communication","Cell Movement","Glioblastoma","Humans","Neoplasm Transplantation","Organoids","Coculture Techniques","Cell Line, Tumor","Receptor-Like Protein Tyrosine Phosphatases, Class 5","Epithelial-Mesenchymal Transition","Tumor Microenvironment"],"keywords":["Organoid","Tumor microenvironment","Transplantation","Glioblastoma","Phenotype","Cell","Brain tumor","Protein tyrosine phosphatase","Ptprz1","Cp: Cancer","Cp: Stem Cell Research","Human Organoid Tumor Transplantation","Organoid Models Of Brain Cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"cellosaurus"},{"name":"uniprot"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T05:49:10.912176Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}