{"doi":"10.1016/j.celrep.2025.116694","title":"Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling","abstract":"Neuronal responses to stimuli rely on transcriptional programs controlled by histone proteins, including histone variants. Recent findings demonstrate that the variant H2BE promotes transcription and is critical for long-term memory, which relies on intact activity-dependent responses. However, whether H2BE is regulated by synaptic stimuli and controls activity-dependent responses remains to be determined. Here, we demonstrate that, unlike other variants, H2BE is depleted following long-term but not short-term increases in activity, indicating that its loss may promote homeostatic downscaling. Neurons lacking H2BE are unable to mount proper long-term activity-dependent transcriptional responses both in cultured neurons and in animal models. Lastly, we demonstrate that H2BE-knockout neurons fail to undergo the electrophysiological changes associated with homeostatic plasticity. In summary, these data demonstrate that H2BE expression is inversely correlated with activity and is necessary for long-term activity-dependent scaling responses, revealing a mechanism through which histone variants control homeostatic plasticity in neurons.","journal":"Cell Reports","year":2025,"id":585884,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":482735,"name":"Alekh Paranjapye","orcid":"0000-0002-4069-1761","position":1,"is_corresponding":false},{"id":618509,"name":"Annabel K. Sangree","orcid":"0000-0002-0298-1856","position":2,"is_corresponding":false},{"id":1414078,"name":"Rili Ahmad","orcid":null,"position":3,"is_corresponding":false},{"id":1413666,"name":"Marissa J. Maroni","orcid":"0000-0001-5295-8307","position":4,"is_corresponding":false},{"id":1072637,"name":"Qi Qiu","orcid":"0000-0002-0933-4707","position":5,"is_corresponding":false},{"id":1055172,"name":"Kyuhyun Choi","orcid":"0000-0003-0605-2437","position":6,"is_corresponding":false},{"id":364326,"name":"Marc V. Fuccillo","orcid":"0000-0002-6569-706X","position":7,"is_corresponding":false},{"id":271815,"name":"Hao Wu","orcid":"0000-0001-7804-8205","position":8,"is_corresponding":false},{"id":844503,"name":"Erica Korb","orcid":"0000-0002-7064-8123","position":9,"is_corresponding":false},{"id":1238466,"name":"Emily Feierman","orcid":"0000-0002-2133-5825","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:59:24.273134Z","pmid":"41422507","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}