{"doi":"10.1016/j.celrep.2025.116653","title":"ESAT-6 and CFP-10 reactive IgG in patients with tuberculosis inhibits intracellular bacteria","abstract":"Perspectives beyond the CD4 T cell interferon (IFN)-γ paradigm are needed to understand immunity in tuberculosis (TB). Growing data in patients across a spectrum of TB highlight that changes in antibody Fc domain glycosylation and Fc effector functions correlate with disease and impact Mycobacterium tuberculosis (Mtb) infection. How antigen-specific antibodies within polyclonal responses affect bacteria is less clear. This study examines antibodies targeting ESAT-6 and CFP-10, Mtb virulence proteins essential for pathogenesis. Data from patients with TB show that polyclonal immunoglobulin (Ig)G reactive to ESAT-6 and CFP-10 diverges from other Mtb and non-Mtb antigens with enhanced sialylation, afucosylation, natural killer cell-mediated cellular cytotoxicity, and association with anti-microbial activity against intracellular Mtb. Monoclonal antibody studies show that intracellular Mtb inhibition is dependent on antigen binding, N-linked glycans, and Fc-Fc receptor (FcR) engagement. These findings demonstrate that some antibodies in patients inhibit Mtb in its quintessential intracellular niche, opening avenues to appreciate how humoral immunity impacts TB.","journal":"Cell Reports","year":2025,"id":529512,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":782757,"name":"Pei Lu","orcid":"0000-0002-7682-4757","position":1,"is_corresponding":false},{"id":807444,"name":"Shuangyi Bai","orcid":null,"position":2,"is_corresponding":false},{"id":362686,"name":"Génesis P. Aguillón-Durán","orcid":null,"position":3,"is_corresponding":false},{"id":1138669,"name":"Javier E. Rodríguez-Herrera","orcid":null,"position":4,"is_corresponding":false},{"id":283936,"name":"Bronwyn M. Gunn","orcid":"0000-0001-8904-9334","position":5,"is_corresponding":false},{"id":297929,"name":"Blanca I. Restrepo","orcid":"0000-0002-3743-9098","position":6,"is_corresponding":false},{"id":297926,"name":"Lenette L. Lu","orcid":"0000-0003-4658-1261","position":7,"is_corresponding":false},{"id":505246,"name":"Joshua Miles","orcid":"0000-0003-0022-1965","position":0,"is_corresponding":true}],"reference_count":148,"raw_metadata":null,"created_at":"2026-07-19T02:50:56.971987Z","pmid":"41370123","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}