{"doi":"10.1016/j.celrep.2025.116641","title":"Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy","abstract":"Once considered mere scaffolds, mesenchymal stromal cells are now recognized as actively shaping airway immunity. We identify adventitial fibroblasts (AFs) in perivascular/peribronchial cuffs as a dominant source of complement C3. At baseline, a discrete subset of AF co-expresses C3 and IL-33. Upon allergen exposure, these C3 + IL-33 + AFs expand and increase their production of both C3 and IL-33, indicating a shift toward an allergic AF phenotype. Disruption of C3 production in AFs abrogates IL-33 expression, underscoring the essential role C3 plays in maintaining an allergic AF phenotype. Functionally, C3 from AFs is required to drive allergen-induced group 2 innate lymphoid cell (ILC2) responses. C3 + AFs not only support ILC2s but are also influenced by ILC2-derived IL-13, which, in turn, promotes AF function, perpetuating the allergic response. These findings reveal that aberrant C3 production by the adventitial stroma orchestrates a pathogenic AF-ILC2 niche that promotes allergic inflammation.","journal":"Cell Reports","year":2025,"id":529452,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1329502,"name":"Aishwarya Magesh","orcid":"0009-0003-7103-7206","position":1,"is_corresponding":false},{"id":737781,"name":"Hwan Mee Yong","orcid":null,"position":2,"is_corresponding":false},{"id":1408267,"name":"Elizabeth Murray","orcid":"0000-0001-8903-575X","position":3,"is_corresponding":false},{"id":251571,"name":"Naina Gour","orcid":"0000-0003-3853-4377","position":4,"is_corresponding":false},{"id":251570,"name":"Stéphane Lajoie","orcid":"0000-0002-0514-1801","position":5,"is_corresponding":false},{"id":1211749,"name":"Aishwarya Atakkatan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T02:50:56.971987Z","pmid":"41319296","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}