{"doi":"10.1016/j.celrep.2025.116595","title":"Organoid-based precision cancer modeling: New frontier in lung cancer research","abstract":"Lung cancer remains a leading cause of cancer-related mortality globally, underscoring the need for advanced preclinical models that accurately recapitulate disease biology. Recent advances in organoid technology have enabled the establishment of patient-derived lung cancer organoids (LCOs), which faithfully reproduce the histological, genetic, and phenotypic features of primary tumors. This organoid-based precision modeling facilitates deeper insights into tumor biology and disease progression, supporting the identification of novel therapeutic targets and biomarkers. In this review, we summarize recent progress in LCO-based precision modeling, focusing on their ability to preserve tumor heterogeneity, link genotype and phenotype through multi-omics integration, and explore tumor-microenvironment interactions via gene editing and co-culture systems. We also highlight the growing importance of LCO biobanks and international collaborations in translational research. Despite challenges such as low establishment efficiency, LCO-based precision modeling offers a powerful platform for understanding lung cancer pathogenesis and guiding the development of more effective therapies.","journal":"Cell Reports","year":2025,"id":3764,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0629,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-12-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":38043,"name":"Hiroyuki Yasuda","orcid":null,"position":1,"is_corresponding":false},{"id":38044,"name":"Toshiro Sato","orcid":"0000-0001-8353-8137","position":2,"is_corresponding":false},{"id":38042,"name":"Hideki Terai","orcid":"0000-0002-1118-1930","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}