{"doi":"10.1016/j.celrep.2025.116554","title":"Genetic and chromatin regulation of Pvt1 monoallelic expression","abstract":"While most genes are equivalently expressed on both alleles, genes with random monoallelic expression (RME) stably maintain expression from only one allele, but the mechanisms and consequences of RME remain unclear. We performed allele-specific RNA sequencing (RNA-seq) on ∼100 F 1 hybrid neural progenitor cell (NPC) clonal lines to reveal the extent of autosomal RME (aRME). Of the 287 aRME genes, Pvt1 , an oncogenic long non-coding RNA, is an aRME with a genetic bias. In the absence of genetic differences, Pvt1 undergoes balanced aRME. Pvt1 monoallelic expression is maintained by allele-specific active and repressive histone modifications, opposed to DNA methylation. Additionally, we provide a two-step mechanism for the initiation of aRME and demonstrate that Pvt1 monoallelic expression results in a growth phenotype due to the interplay with Myc . These findings provide insight into how genetic differences can skew a stochastic process, resulting in monoallelic expression with a phenotypic consequence in early development.","journal":"Cell Reports","year":2025,"id":548509,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1442213,"name":"Mason Chen","orcid":null,"position":1,"is_corresponding":false},{"id":262617,"name":"Julia A. Belk","orcid":"0000-0003-4724-6158","position":2,"is_corresponding":false},{"id":554420,"name":"Katerina Kraft","orcid":"0000-0002-2011-6946","position":3,"is_corresponding":false},{"id":676580,"name":"Anne-Valérie Gendrel","orcid":"0000-0003-4510-0024","position":4,"is_corresponding":false},{"id":44861,"name":"Édith Heard","orcid":"0000-0001-8052-7117","position":5,"is_corresponding":false},{"id":239678,"name":"Joanna Wysocka","orcid":"0000-0002-6909-6544","position":6,"is_corresponding":false},{"id":26,"name":"Howard Y. Chang","orcid":"0000-0002-9459-4393","position":7,"is_corresponding":false},{"id":557222,"name":"Christy Luong","orcid":"0000-0003-2841-9930","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:53:58.530220Z","pmid":"41223055","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}