{"doi":"10.1016/j.celrep.2025.116501","title":"Mpox-specific cellular and humoral immunity in mpox survivors living with HIV","abstract":"The 2022 mpox virus (MPXV) outbreak caused life-threatening mpox disease in people living with HIV (PLWH). We compared immune responses to MPXV in PLWH who were either mpox-naive or were mpox survivors. We characterized the magnitude, polyfunctionality, and cytolytic potential of CD4 and CD8 T cells specific to MPXV and cross-reactive orthopoxviral antigens and compared them to HIV- and cytomegalovirus (CMV)-specific T cells. Mpox survivors developed MPXV-specific CD4 T cells capable of producing IFNγ, TNFα, and IL-2. Their polyfunctionality was superior to CMV-specific CD4 T cells. MPXV- and CMV-specific CD8 T cells had similar cytolytic potentials. Importantly, mpox survivors developed strong MPXV-specific antibodies with neutralizing activity. Prior vaccinia or JYNNEOS vaccination was associated with greater MPXV-specific antibody but not T cells. These data demonstrate that PLWH generate functional cellular and humoral immunity to MPXV post-mpox. Despite their immunocompromised state, mpox survivors with HIV are expected to have some protection against future MPXV exposures.","journal":"Cell Reports","year":2025,"id":529225,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":337022,"name":"Lalita Priyamvada","orcid":"0000-0002-0479-0164","position":1,"is_corresponding":false},{"id":1408534,"name":"Shainy Sambyal","orcid":null,"position":2,"is_corresponding":false},{"id":253811,"name":"Sailaja Gangadhara","orcid":"0000-0001-8603-628X","position":3,"is_corresponding":false},{"id":1408535,"name":"Margaret Moriarty","orcid":null,"position":4,"is_corresponding":false},{"id":337024,"name":"Panayampalli S. Satheshkumar","orcid":"0000-0003-1472-1418","position":5,"is_corresponding":false},{"id":292649,"name":"Alba Grifoni","orcid":"0000-0002-2209-5966","position":6,"is_corresponding":false},{"id":55670,"name":"Alessandro Sette","orcid":"0000-0001-7013-2250","position":7,"is_corresponding":false},{"id":301948,"name":"Anandi N. Sheth","orcid":"0000-0002-6305-2727","position":8,"is_corresponding":false},{"id":340072,"name":"Colleen F. Kelley","orcid":"0000-0001-5611-0119","position":9,"is_corresponding":false},{"id":253824,"name":"Rama Rao Amara","orcid":"0000-0002-6309-6797","position":10,"is_corresponding":false},{"id":541116,"name":"Samuel D. Stampfer","orcid":"0000-0001-7365-6754","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:50:56.971987Z","pmid":"41176764","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}