{"doi":"10.1016/j.celrep.2025.116412","title":"CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms","abstract":"During T cell activation, mitochondrial biogenesis and cellular metabolism are altered to meet the elevated energy demands of protein synthesis, rapid proliferation, and effector T cell function. The mechanisms coupling mitochondrial dynamics to T cell status are unclear. Here, we report that RNA cap methyltransferase 1 (CMTR1) is induced in activated T cells, methylating the first nucleotide on mRNA and U2 small nuclear RNA (snRNA), a component of the spliceosome. Using transcriptomic analyses, we identify a functional splicing module regulating mitochondrial dynamics in T cells, which alters the isoforms of proteins controlling mitochondrial fission and fusion. Through epitranscriptomic control of U2 snRNA and splicing, CMTR1 directs protein isoform selection during T cell activation to promote the development of longer mitochondria with increased respiratory capacity. Thus, CMTR1 upregulation supports the energetic demands of T cell activation, survival, and immune responses.","journal":"Cell Reports","year":2025,"id":535066,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":33799,"name":"Katarzyna Knop","orcid":"0000-0002-2636-9450","position":1,"is_corresponding":false},{"id":1418221,"name":"Carolina Gómez-Moreira","orcid":"0000-0002-5700-1130","position":2,"is_corresponding":false},{"id":1418677,"name":"Vanessa Xavier","orcid":null,"position":3,"is_corresponding":false},{"id":1418222,"name":"Sarah Thomson","orcid":"0000-0003-0549-1104","position":4,"is_corresponding":false},{"id":134273,"name":"Harunori Yoshikawa","orcid":"0000-0003-3793-6219","position":5,"is_corresponding":false},{"id":1418678,"name":"Olga Suska","orcid":null,"position":6,"is_corresponding":false},{"id":1418223,"name":"Radoslaw Lukoszek","orcid":"0000-0002-5049-231X","position":7,"is_corresponding":false},{"id":1418679,"name":"Aneesa Kaskar","orcid":null,"position":8,"is_corresponding":false},{"id":65596,"name":"Angus I. Lamond","orcid":"0000-0001-6204-6045","position":9,"is_corresponding":false},{"id":1418224,"name":"Thomas MacVicar","orcid":"0000-0001-9846-6359","position":10,"is_corresponding":false},{"id":17947,"name":"Victoria H. Cowling","orcid":"0000-0001-7638-4870","position":11,"is_corresponding":false},{"id":1418220,"name":"Alison Galloway","orcid":"0000-0001-8780-0382","position":0,"is_corresponding":true}],"reference_count":95,"raw_metadata":null,"created_at":"2026-07-19T02:51:52.019261Z","pmid":"41091598","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}