{"doi":"10.1016/j.celrep.2025.116316","title":"CD7 regulates the persistence of terminally exhausted CD8+ T cells during chronic infection","abstract":"CD8 + T cell exhaustion limits immune responses during cancer and chronic infection. We identify CD7 as a tissue-specific regulator of terminally exhausted CD8 + T cells during chronic infection. CD7 expression progressively increases during exhaustion, reaching its highest levels on a subset of CD101 + Tim3 low terminally exhausted cells that arise in the liver. Transcriptomic analysis revealed that CD7-deficient terminally exhausted cells display altered expression of co-stimulatory, translational, and effector genes, correlating with markedly reduced persistence and increased apoptotic susceptibility. Importantly, CD7 is preferentially upregulated on PD-1 + CD39 + tumor-infiltrating lymphocytes in human head and neck squamous cell carcinoma, suggesting that CD7 may play a conserved role in promoting exhausted T cell survival. These findings reveal a function for CD7 in sustaining terminally exhausted CD8 + T cells and demonstrate that CD7 signaling is a critical regulator of T cell persistence during chronic infection.","journal":"Cell Reports","year":2025,"id":530850,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":701948,"name":"Colby J. Hofferek","orcid":"0000-0002-1051-0827","position":1,"is_corresponding":false},{"id":1410799,"name":"Maria Stegantseva","orcid":"0000-0002-8692-3767","position":2,"is_corresponding":false},{"id":1411200,"name":"Emerald Kan","orcid":null,"position":3,"is_corresponding":false},{"id":620600,"name":"Kelli A. McCord","orcid":"0000-0001-6833-1509","position":4,"is_corresponding":false},{"id":1360417,"name":"Víctor Asensi","orcid":"0000-0003-4211-456X","position":5,"is_corresponding":false},{"id":640979,"name":"Amanda Y. Xia","orcid":"0000-0002-3344-7699","position":6,"is_corresponding":false},{"id":1293719,"name":"Jacob P. Conarty","orcid":null,"position":7,"is_corresponding":false},{"id":241860,"name":"Andreas Wieland","orcid":"0000-0001-9648-7922","position":8,"is_corresponding":false},{"id":226154,"name":"William Henry Hudson","orcid":"0000-0002-2513-1213","position":9,"is_corresponding":false},{"id":740082,"name":"Sean Hyslop","orcid":"0000-0002-6993-3795","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T02:51:10.077559Z","pmid":"40974572","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}