{"doi":"10.1016/j.celrep.2025.116262","title":"Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12","abstract":"to ensure robust NRF2 degradation. In this manner, TRIP12 accelerates stress response silencing as oxidative stress is being resolved but limits NRF2 activation during stress. The need for dynamic control of NRF2 degradation therefore comes at the cost of diminished stress signaling, suggesting that TRIP12 inhibition could be used to treat degenerative pathologies characterized by ROS accumulation.","journal":"Cell Reports","year":2025,"id":518705,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1387076,"name":"Devlon M. McCloud","orcid":null,"position":1,"is_corresponding":false},{"id":941255,"name":"Jane Hu","orcid":"0000-0002-7710-9317","position":2,"is_corresponding":false},{"id":248007,"name":"Michael Rapé","orcid":"0000-0003-4849-6343","position":3,"is_corresponding":false},{"id":661865,"name":"Andrew J. Ingersoll","orcid":"0000-0002-2796-0779","position":0,"is_corresponding":true}],"reference_count":104,"raw_metadata":null,"created_at":"2026-07-19T02:49:14.184995Z","pmid":"40928944","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}