{"doi":"10.1016/j.celrep.2025.116254","title":"FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation","abstract":"High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However, the immunoregulatory effects of different HFDs on psoriasis pathogenesis remains poorly understood. Here, mimicking human dietary fat profiles, four HFDs-saturated, monounsaturated, omega-6, and omega-3 fats-were designed and used to induce obesity in mice. Despite comparable obesity levels across groups, only the saturated HFD exacerbated imiquimod (IMQ)-induced psoriasis. This exacerbation correlated with elevated levels of IL-1β-producing macrophages, IL-17A-producing γδ T cells, and neutrophils within psoriatic lesions. Mechanistically, saturated fatty acids (FAs) promoted IL-1β/IL-17A signaling via fatty acid-binding protein 5 (FABP5)-mediated mitochondrial FA oxidation and extracellular ATP release in skin macrophages. Deletion of FABP5, either globally or specifically in macrophages, attenuated IL-1β/IL-17A signaling and alleviated IMQ-induced psoriasis. These findings identify FABP5 as a key mediator of saturated HFD-driven psoriasis via the IL-1β/IL-17 axis, offering insights into the interplay between dietary fats, obesity, and psoriasis.","journal":"Cell Reports","year":2025,"id":514492,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9454,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":256401,"name":"Jiaqing Hao","orcid":"0000-0002-2834-7255","position":1,"is_corresponding":false},{"id":896238,"name":"Matthew S. Yorek","orcid":"0000-0002-4737-9367","position":2,"is_corresponding":false},{"id":1222921,"name":"Xingshan Jiang","orcid":"0009-0000-1590-6794","position":3,"is_corresponding":false},{"id":1222923,"name":"Anthony M. Avellino","orcid":"0000-0001-9072-9660","position":4,"is_corresponding":false},{"id":353446,"name":"Shanshan Liu","orcid":"0009-0007-0775-5616","position":5,"is_corresponding":false},{"id":1300384,"name":"Xiaochun Han","orcid":"0009-0006-8926-648X","position":6,"is_corresponding":false},{"id":1370907,"name":"Jonathan Shilyansky","orcid":"0009-0006-2155-0011","position":7,"is_corresponding":false},{"id":1205610,"name":"Zhaohua Wang","orcid":"0000-0001-6524-6130","position":8,"is_corresponding":false},{"id":456229,"name":"Yuhang Wang","orcid":"0000-0003-3715-8349","position":9,"is_corresponding":false},{"id":608835,"name":"Zizhen Kang","orcid":"0000-0001-5621-8912","position":10,"is_corresponding":false},{"id":454548,"name":"Ali Jabbari","orcid":"0000-0002-8559-7314","position":11,"is_corresponding":false},{"id":1377126,"name":"Bing Li","orcid":"0009-0003-7645-149X","position":12,"is_corresponding":false},{"id":763558,"name":"Jianyu Yu","orcid":"0000-0002-1856-2189","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:48:29.165853Z","pmid":"40913763","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}