{"doi":"10.1016/j.celrep.2025.116248","title":"The dorsal column nuclei encode and transmit the network signatures of mechanical allodynia","abstract":"The neural circuits that transmit the sense of pain and how pain is encoded by these circuits are still poorly understood.Mechanical allodynia is a prominent form of chronic pain characterized by painful responses to innocuous touch that develops as a consequence of nerve damage and inflammation. Here, we show that alterations to the normal log-normal distribution of neuronal activity and structure of neural correlations between neurons in the dorsal column nuclei (DCN) constitute a signature feature of mechanical allodynia, with the transmission of \"allodynic\" light touch information to the thalamus by somatostatin-positive projection neurons in the DCN being essential for its expression and development. Our findings are consistent with neural activity in the DCN encoding a reference landscape of tactile percepts that animals use to differentiate innocuous touch from potentially noxious mechanical stimuli.","journal":"Cell Reports","year":2025,"id":546666,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1367011,"name":"Tejapratap Bollu","orcid":"0000-0002-4945-3962","position":1,"is_corresponding":false},{"id":1032386,"name":"Xiangyu Ren","orcid":"0000-0001-5497-5194","position":2,"is_corresponding":false},{"id":9862,"name":"A. Palma","orcid":"0009-0008-4332-9179","position":3,"is_corresponding":false},{"id":236877,"name":"Martyn Goulding","orcid":"0000-0001-7950-409X","position":4,"is_corresponding":false},{"id":671279,"name":"Amandine Virlogeux","orcid":"0000-0002-7419-6822","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T02:53:36.567932Z","pmid":"40914940","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}