{"doi":"10.1016/j.celrep.2025.116189","title":"A vascular-associated fibroblastic cell controls pancreatic islet immunity","abstract":"The immune protection of pancreatic β cells has three layers: anatomical, with their distribution in 1 million islets; central, with the thymic deletion of β cell-specific T cells; and peripheral, with inhibitory cellular networks. The failure of the latter leads to most spontaneous type 1 diabetes and all diabetes induced by checkpoint inhibitor therapy. Because CD4 T cells initiate disease, major histocompatibility complex (MHC) class II-expressing cells are central to the onset. In non-diabetic mouse and human islets, two such cells were detected outside of the islet boundaries near the efferent post-capillary venules: one related to the vasculature and a fibroblast referred to as a \"vascular-associated fibroblast\" (VAF). Functionally, primary VAFs spontaneously presented islet antigens to CD4 T cells and expressed high levels of inhibitory B7 receptors and no costimulatory receptors. VAFs induced anergy in primary pre-activated anti-islet CD4 T cells. VAFs are likely important to protect the endocrine pancreas from autoimmunity.","journal":"Cell Reports","year":2025,"id":573731,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9478,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1076794,"name":"Anne Costanzo","orcid":"0000-0003-1934-5319","position":1,"is_corresponding":false},{"id":987320,"name":"Siddhartha Sharma","orcid":"0000-0001-8597-7547","position":2,"is_corresponding":false},{"id":1076795,"name":"Lisa Kain","orcid":"0000-0001-5873-8647","position":3,"is_corresponding":false},{"id":53135,"name":"Kelley W. Moremen","orcid":"0000-0003-1768-582X","position":4,"is_corresponding":false},{"id":237704,"name":"Jeremy Pettus","orcid":"0000-0002-5999-0091","position":5,"is_corresponding":false},{"id":874800,"name":"Alain Domissy","orcid":"0000-0002-7376-8294","position":6,"is_corresponding":false},{"id":262641,"name":"Peng Wu","orcid":"0000-0002-5204-0229","position":7,"is_corresponding":false},{"id":296524,"name":"Kim-Vy Nguyen-Ngoc","orcid":null,"position":8,"is_corresponding":false},{"id":23927,"name":"Denise A. Berti","orcid":"0009-0003-2196-9240","position":9,"is_corresponding":false},{"id":311780,"name":"Steven C. George","orcid":"0000-0003-2263-1914","position":10,"is_corresponding":false},{"id":281522,"name":"Christopher C.W. Hughes","orcid":"0000-0002-3223-830X","position":11,"is_corresponding":false},{"id":7364,"name":"Maike Sander","orcid":"0000-0001-5308-7785","position":12,"is_corresponding":false},{"id":91049,"name":"Luc Teyton","orcid":"0000-0002-4049-1583","position":13,"is_corresponding":false},{"id":971179,"name":"Don Clarke","orcid":"0000-0003-1917-1566","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:57:36.753600Z","pmid":"40884792","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}