{"doi":"10.1016/j.celrep.2025.116049","title":"Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts","abstract":"Transitions from hunger to satiety involve multiple behavioral changes, including modulation and inhibition of feeding behavior. In mammals, cholecystokinin (CCK) is a key satiety peptide implicated in these processes; however, whether and how CCK might induce satiety via synaptic and intrinsic plasticity remains unclear. Here, we investigate CCK-type signaling in the protostome mollusk Aplysia californica. We demonstrate that Aplysia CCK (apCCK) acts as a conserved brain-gut peptide. Gut-localized apCCK-expressing neurons project centrally and release apCCK near the feeding-pattern generator. In vivo, apCCK suppresses food intake, while in vitro, it shifts motor output toward egestive patterns and inhibits feeding programs. Mechanistically, apCCK modulates the excitability of the egestive-promoting B20 interneuron and suppresses synaptic input to protraction-phase motoneurons, thereby altering program selection and inhibiting feeding-program generation. These findings highlight the importance of both synaptic and intrinsic plasticity in specific circuit elements for implementing motivational shifts driven by satiety signaling.","journal":"Cell Reports","year":2025,"id":521693,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1128814,"name":"Xueying Ding","orcid":"0000-0002-8366-7059","position":1,"is_corresponding":false},{"id":666284,"name":"Elena V. 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