{"doi":"10.1016/j.celrep.2025.115780","title":"Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells","abstract":"regulatory T cells (Tregs), while the rest fail to induce pathology. Here, single-cell transcriptomics and functional validation revealed distinct phenotypes in both populations: ocular Tregs were highly suppressive, whereas non-Tregs expressed suppression- and anergy-associated genes and lacked regulatory function. Trajectory analyses suggested that Tregs and anergic cells arise from a common proliferative precursor in parallel, rather than sequentially. Our data indicate a key checkpoint governing the divergence of anergic and regulatory fates. These findings provide molecular-level insights into ocular immune privilege and may inform strategies to silence autoimmune effector cells or reverse T cell unresponsiveness in cancer, vaccination, or chronic infection.","journal":"Cell Reports","year":2025,"id":512547,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9412,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":974314,"name":"Vijayaraj Nagarajan","orcid":null,"position":1,"is_corresponding":false},{"id":251059,"name":"Reiko Horai","orcid":"0000-0001-9382-4444","position":2,"is_corresponding":false},{"id":251056,"name":"Yingyos Jittayasothorn","orcid":"0000-0001-6977-2728","position":3,"is_corresponding":false},{"id":251051,"name":"Mary J. Mattapallil","orcid":"0000-0003-0615-7343","position":4,"is_corresponding":false},{"id":251060,"name":"Rachel R Caspi","orcid":"0000-0002-7140-7671","position":5,"is_corresponding":false},{"id":1372077,"name":"Zixuan Peng","orcid":"0000-0003-3864-2765","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-19T02:48:06.263458Z","pmid":"40450686","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}