{"doi":"10.1016/j.celrep.2025.115613","title":"Anti-dengue virus antibodies that elicit complement-mediated lysis of Zika virion correlate with protection from severe dengue disease","abstract":"Antibodies from primary dengue (DENV1-4) or Zika (ZIKV) virus infections can influence subsequent heterotypic infections, but their protective characteristics are not well defined. We analyzed pre-infection plasma samples from children in our Nicaraguan cohort study who later developed either dengue fever (DF; n = 31) or dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS; n = 33) upon secondary heterotypic DENV infection. Various antibody properties, notably antibody-dependent complement deposition, correlated with protection against DHF/DSS. Interestingly, this association was strongest when using recombinant ZIKV antigens despite participants being ZIKV naive. Additionally, complement-mediated virion lysis (virolysis) with ZIKV virions was strongly associated with protection, a finding replicated in an independent sample set. ZIKV virolysis emerged as the only antibody property linked to reduced risk of DHF/DSS and severe symptoms such as thrombocytopenia and plasma leakage. These results suggest that ZIKV-cross-reactive anti-DENV antibodies that mediate complement-dependent virolysis may lower the risk of severe disease, informing the development of effective dengue vaccines and therapeutics.","journal":"Cell Reports","year":2025,"id":519490,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242449,"name":"Elias Duarte","orcid":"0000-0003-2541-5504","position":1,"is_corresponding":false},{"id":972152,"name":"José Víctor Zambrana","orcid":"0000-0003-0107-6173","position":2,"is_corresponding":false},{"id":794008,"name":"Jaime A. Cardona‐Ospina","orcid":"0000-0003-3996-2293","position":3,"is_corresponding":false},{"id":343703,"name":"Sandra Bos","orcid":"0000-0001-5036-0336","position":4,"is_corresponding":false},{"id":320206,"name":"Vicky Roy","orcid":"0000-0002-5064-1098","position":5,"is_corresponding":false},{"id":1217108,"name":"Julia Huffaker","orcid":"0009-0008-8939-1971","position":6,"is_corresponding":false},{"id":236672,"name":"Guillermina Kuan","orcid":"0000-0002-5251-173X","position":7,"is_corresponding":false},{"id":549931,"name":"Ángel Balmaseda","orcid":"0009-0006-3812-5978","position":8,"is_corresponding":false},{"id":106757,"name":"Galit Alter","orcid":"0000-0002-7680-9215","position":9,"is_corresponding":false},{"id":236674,"name":"Eva Harris","orcid":"0000-0002-7238-4037","position":10,"is_corresponding":false},{"id":858156,"name":"Antônio Gregorio Dias","orcid":"0000-0003-4392-4206","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T02:49:18.751199Z","pmid":"40333188","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}