{"doi":"10.1016/j.celrep.2025.115499","title":"A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein","abstract":"The Coronavirus Immunotherapeutic Consortium (CoVIC) conducted side-by-side comparisons of over 400 anti-SARS-CoV-2 spike therapeutic antibody candidates contributed by large and small companies as well as academic groups on multiple continents. Nine reference labs analyzed antibody features, including in vivo protection in a mouse model of infection, spike protein affinity, high-resolution epitope binning, ACE-2 binding blockage, structures, and neutralization of pseudovirus and authentic virus infection, to build a publicly accessible dataset in the database CoVIC-DB. High-throughput, high-resolution binning of CoVIC antibodies defines a broad and predictive landscape of antibody epitopes on the SARS-CoV-2 spike protein and identifies features associated with durable potency against multiple SARS-CoV-2 variants of concern and high in vivo efficacy. Results of the CoVIC studies provide a guide for selecting effective and durable antibody therapeutics and for immunogen design as well as providing a framework for rapid response to future viral disease outbreaks.","journal":"Cell Reports","year":2025,"id":514217,"datarank":0.39855067195714994,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.06896698535671696,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.06896698535671696,"corpus_percentile":54.11154947010134,"corpus_rank":5933,"citation_count":8,"citer_count":6,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.9021,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":41.6667,"fair_percentile":54.173035768878016,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":371896,"name":"Xiaoying Yu","orcid":"0000-0003-1659-2365","position":1,"is_corresponding":false},{"id":107104,"name":"Peter Halfmann","orcid":"0000-0002-1648-1625","position":2,"is_corresponding":false},{"id":895553,"name":"Jarjapu Mahita","orcid":null,"position":3,"is_corresponding":false},{"id":1040896,"name":"Brendan Ha","orcid":null,"position":4,"is_corresponding":false},{"id":103730,"name":"Kathryn M. 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Pino","orcid":"0000-0001-8626-926X","position":25,"is_corresponding":false},{"id":945549,"name":"Amberlee Hicks","orcid":null,"position":26,"is_corresponding":false},{"id":2361,"name":"Chengjin Ye","orcid":"0000-0002-1934-9494","position":27,"is_corresponding":false},{"id":555172,"name":"Jun-Gyu Park","orcid":null,"position":28,"is_corresponding":false},{"id":1377433,"name":"Billie Maingot","orcid":null,"position":29,"is_corresponding":false},{"id":702538,"name":"Sivakumar Periasamy","orcid":"0000-0002-7038-5140","position":30,"is_corresponding":false},{"id":376982,"name":"Michael L. Mallory","orcid":"0000-0003-0768-572X","position":31,"is_corresponding":false},{"id":254645,"name":"Trevor Scobey","orcid":"0000-0001-8313-5434","position":32,"is_corresponding":false},{"id":1377434,"name":"Marie-Noelle Lepage","orcid":null,"position":33,"is_corresponding":false},{"id":806080,"name":"Natalie St-Amant","orcid":null,"position":34,"is_corresponding":false},{"id":1376802,"name":"S. Khan","orcid":"0000-0002-6578-8471","position":35,"is_corresponding":false},{"id":1205229,"name":"Anaïs Gambiez","orcid":null,"position":36,"is_corresponding":false},{"id":5952,"name":"Ralph S. Baric","orcid":"0000-0001-6827-8701","position":37,"is_corresponding":false},{"id":235604,"name":"Alexander Bukreyev","orcid":"0000-0002-0342-4824","position":38,"is_corresponding":false},{"id":806081,"name":"Luc Gagnon","orcid":null,"position":39,"is_corresponding":false},{"id":618446,"name":"Timothy Germann","orcid":"0000-0001-8128-361X","position":40,"is_corresponding":false},{"id":107110,"name":"Yoshihiro Kawaoka","orcid":"0000-0001-5061-8296","position":41,"is_corresponding":false},{"id":258351,"name":"Georgia D. Tomaras","orcid":"0000-0001-8076-1931","position":42,"is_corresponding":false},{"id":34766,"name":"Bjoern Peters","orcid":"0000-0002-8457-6693","position":43,"is_corresponding":false},{"id":104945,"name":"Erica Ollmann Saphire","orcid":"0000-0002-1206-7451","position":44,"is_corresponding":false},{"id":90279,"name":"Sharon L. Schendel","orcid":"0000-0002-5062-7261","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:48:29.165853Z","pmid":"40184253","pmcid":"PMC12014896","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":61.1111,"fair_a":81.25,"fair_i":20.0,"fair_r":33.3333,"fair_zscore":0.2857,"fair_rationale":{"fair_score":41.67,"has_llm":true,"taxonomy_version":"fair_taxonomy_v5","dimensions":{"F":{"name":"Findable","score":61.11,"criteria":[{"key":"f_dataset_pid","label":"Persistent identifier for the data","kind":"llm","weight":2.0,"fraction":0.5,"verdict":"partial","evidence":"All reported data reported are publicly available at the CoVIC-DB ( https://covicdb.lji.org/ ).","grounded":true,"rationale":"The paper gives a web address (URL) for the data, not a persistent identifier scheme (DOI, Handle, etc.). 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CoVIC epitope community, in vivo survival, neutralization, affinity, and ACE-2 blockage data","why":"Variable-level definitions live inside the article as a supplementary table (Table S1), but no separate documentation object (README, codebook) is said to accompany the deposited data. [majority verdict 'partial' (3/5 passes agreed)]","gain":0.0,"priority":"important","scored":false},{"key":"a_controlled_access_for_sensitive","dimension":"A","label":"Gatekeeper for sensitive data","action":"Route sensitive data through an institutional gatekeeper — deposit in a controlled- access repository (dbGaP, EGA) with a Data Access Committee and a published DUA — rather than through the corresponding author's inbox. An author-gated dataset dies with the author's email address, and 'on reasonable request' has been shown repeatedly not to yield data. For sensitive/human clinical / human-subjects data, use a controlled-access repository such as dbGaP or EGA.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"The paper does not indicate the data are sensitive or require controlled access; data are publicly available.","gain":0.0,"priority":"useful","scored":false},{"key":"a_timeline_retention","dimension":"A","label":"Availability timing & retention","action":"State when the data become available AND how long they will be retained — cite the repository's preservation policy. NIH DMS Element 4 asks for both; most papers give neither.","anchors":["yes","partial","no"],"verdict":"partial","current":0.5,"evidence":"All reported data reported are publicly available at the CoVIC-DB ( https://covicdb.lji.org/ ).","why":"The text states the data are currently available but gives no persistence commitment. [majority verdict 'partial' (3/5 passes agreed)]","gain":0.0,"priority":"useful","scored":false}],"suggestions":["Attach a standard, machine-readable open licence to the deposit — CC0 or CC BY, which is what Horizon Europe and most funders expect — and print the licence identifier in the paper. 'Free to use' is not a licence: it grants nothing a reuser's institution can rely on.","Mint or cite a persistent identifier for the dataset — a repository DOI or an accession from a registered repository — and print it in the paper. A bare URL is not persistent: it is the single most common cause of a dead data link five years after publication. For clinical / human-subjects data, deposit in dbGaP or the European Genome-phenome Archive (EGA).","Deposit the data in a repository registered in re3data/FAIRsharing (a domain repository such as GEO, SRA, dbGaP, PRIDE, or a generalist such as Zenodo, Dryad, Dataverse) and name it explicitly in the paper. A lab website is not an archive: it has no retention commitment and no accession. For clinical / human-subjects data, deposit in dbGaP or the European Genome-phenome Archive (EGA).","Release the data in an open, community-standard format (CSV/TSV, JSON, HDF5, NetCDF, FASTQ, VCF, NIfTI…) instead of — or alongside — any proprietary or instrument-native format, and name the format in the paper. A dataset that needs a €2,000 licence to open is not reusable.","Publish the analysis code in a public forge, archive a tagged release with a DOI (Zenodo/Software Heritage), and cite that DOI in the paper. NIH DMS Element 2 asks for the tools and code, not only the data — and 'available on request' is not a locator. Archive the analysis code in a versioned repository (GitHub + a Zenodo release DOI)."],"model":"deepseek/deepseek-v4-flash","agent_version":"fair_agent_v8","fulltext_source":"epmc_xml"},"fair_model":"deepseek/deepseek-v4-flash","fair_agent_version":"fair_agent_v8","fair_fulltext_source":"epmc_xml","fair_has_llm":true,"fair_computed_at":"2026-07-20T12:38:59.664150Z","clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}