{"doi":"10.1016/j.celrep.2025.115472","title":"Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection","abstract":"Memory lymphocytes are durable cells that persist in the absence of antigen, but few human B cell subsets have been characterized in terms of durability. The relative durability of eight non-overlapping human B cell sub-populations covering 100% of all human class-switched B cells was interrogated. Only two long-lived B cell populations persisted in the relative absence of antigen. In addition to canonical germinal center-derived switched-memory B cells with an IgD − CD27 + CXCR5 + phenotype, a second, non-canonical, but distinct memory population of IgD − CD27 − CXCR5 + DN1 B cells was also durable, exhibited a unique TP63 -linked transcriptional and anti-apoptotic signature, had low levels of somatic hypermutation, but was more clonally expanded than canonical switched-memory B cells. DN1 B cells likely evolved to preserve immunological breadth and may represent the human counterparts of rodent extrafollicular memory B cells that, unlike canonical memory B cells, can enter germinal centers and facilitate B cell and antibody evolution.","journal":"Cell Reports","year":2025,"id":511771,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9383,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":108379,"name":"Hang Liu","orcid":"0000-0002-7352-7407","position":1,"is_corresponding":false},{"id":104325,"name":"Jared Feldman","orcid":"0000-0002-4387-9954","position":2,"is_corresponding":false},{"id":1371134,"name":"Jess Marbourg","orcid":null,"position":3,"is_corresponding":false},{"id":1370548,"name":"Thomas V. 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