{"doi":"10.1016/j.celrep.2025.115384","title":"Cell-type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development","abstract":"conditional deletion (Foxp1 conditional knockout [cKO]) in the mouse cortex leads to overall reduced cortex thickness, alterations in cortical lamination, and changes in the relative thickness of cortical layers. However, the developmental and cell-type-specific mechanisms underlying these changes remained unclear. We find that Foxp1 deletion results in accelerated pseudo-age during early neurogenesis, increased cell cycle exit during late neurogenesis, altered gene expression and chromatin accessibility, and selective migration deficits in a subset of upper-layer neurons. These data explain the postnatal differences observed in cortical layers and relative cortical thickness. We also highlight genes regulated by FOXP1 and their enrichment with high-confidence ASD or synaptic genes. Together, these results underscore a network of neurodevelopmental-disorder-related genes that may serve as potential modulatory targets for postnatal modification relevant to ASDs and FOXP1 syndrome.","journal":"Cell Reports","year":2025,"id":512037,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":707399,"name":"Fatma Ayhan","orcid":"0000-0001-9717-1727","position":1,"is_corresponding":false},{"id":367086,"name":"Nitin Khandelwal","orcid":"0000-0001-7229-4413","position":2,"is_corresponding":false},{"id":996981,"name":"Elliot Outland","orcid":"0000-0002-3869-2992","position":3,"is_corresponding":false},{"id":504436,"name":"Miranda J. Jankovic","orcid":"0000-0002-4441-1632","position":4,"is_corresponding":false},{"id":318183,"name":"Matthew J. Harper","orcid":"0000-0002-0748-5392","position":5,"is_corresponding":false},{"id":29916,"name":"Genevieve Konopka","orcid":"0000-0002-3363-7302","position":6,"is_corresponding":false},{"id":289034,"name":"Ana Ortiz","orcid":"0000-0001-9047-3634","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-19T02:48:01.269605Z","pmid":"40048431","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}