{"doi":"10.1016/j.celrep.2025.115380","title":"Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts","abstract":"Triggering receptor expressed on myeloid cells 1 (TREM-1) has been shown to amplify inflammatory signals, such as Toll-like receptor signaling, after infection and sterile injury. While previous studies have demonstrated that TREM-1 activation in circulating immune cells promotes injury, the role of TREM-1 signaling in tissue-resident cells in the context of sterile inflammation remains poorly understood. Here, we used a cardiac transplantation model to dissect how Trem1/3 expression on heart-resident cells regulates sterile inflammation. TREM-1 is expressed in heart-resident C-C chemokine receptor 2 (CCR2) + macrophages in mice and humans. TREM-1/3 signaling in tissue-resident CCR2 + macrophages promotes C-C motif chemokine ligand 3 (CCL3) production and is critical for recruiting neutrophils and CCR2 + monocytes after heart transplantation. We demonstrate prolonged allograft survival after transplantation of Trem1/3 -deficient compared with wild-type hearts. We identify TREM-1/3 signaling in donor grafts as a potential future therapeutic target to blunt inflammation after myocardial ischemia-reperfusion injury.","journal":"Cell Reports","year":2025,"id":516512,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376146,"name":"Wenjun Li","orcid":"0000-0002-1923-5016","position":1,"is_corresponding":false},{"id":867739,"name":"Junedh Amrute","orcid":"0000-0002-6851-0168","position":2,"is_corresponding":false},{"id":676718,"name":"Amit Bery","orcid":"0000-0002-1020-8839","position":3,"is_corresponding":false},{"id":1381833,"name":"C. Liu","orcid":"0000-0001-8932-8835","position":4,"is_corresponding":false},{"id":1327464,"name":"Venkatrao Nunna","orcid":null,"position":5,"is_corresponding":false},{"id":1381834,"name":"C. Corbin Frye","orcid":"0000-0002-4323-0696","position":6,"is_corresponding":false},{"id":283783,"name":"Hao Dun","orcid":null,"position":7,"is_corresponding":false},{"id":321592,"name":"Andrew L. Koenig","orcid":"0000-0003-4384-1267","position":8,"is_corresponding":false},{"id":273845,"name":"Hannah Luehmann","orcid":"0000-0002-7516-6772","position":9,"is_corresponding":false},{"id":273847,"name":"Gyu Seong Heo","orcid":"0000-0001-6200-4742","position":10,"is_corresponding":false},{"id":990564,"name":"Macee C. Owen","orcid":null,"position":11,"is_corresponding":false},{"id":280878,"name":"Alexander N. Wein","orcid":"0000-0002-8813-3523","position":12,"is_corresponding":false},{"id":273860,"name":"Yongjian Liu","orcid":"0000-0002-1118-1535","position":13,"is_corresponding":false},{"id":107154,"name":"Jon H. Ritter","orcid":"0009-0003-4514-6935","position":14,"is_corresponding":false},{"id":371996,"name":"Sumanth D. Prabhu","orcid":"0000-0002-7247-7241","position":15,"is_corresponding":false},{"id":376148,"name":"Ruben G. Nava","orcid":"0000-0001-5685-9445","position":16,"is_corresponding":false},{"id":230331,"name":"Andrew E. Gelman","orcid":"0000-0002-0711-6343","position":17,"is_corresponding":false},{"id":109978,"name":"Marina Cella","orcid":"0000-0003-1230-1313","position":18,"is_corresponding":false},{"id":71132,"name":"Marco Colonna","orcid":"0000-0001-5222-4987","position":19,"is_corresponding":false},{"id":247530,"name":"Kory J. Lavine","orcid":"0000-0003-1948-9945","position":20,"is_corresponding":false},{"id":273856,"name":"Daniel Kreisel","orcid":"0000-0002-7711-8651","position":21,"is_corresponding":false},{"id":376145,"name":"Yuriko Terada","orcid":"0000-0003-1598-9360","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:48:49.486328Z","pmid":"40042972","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}