{"doi":"10.1016/j.celrep.2025.115366","title":"Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection","abstract":"Dengue-virus-induced humoral immunity can increase the risk of severe disease, but the factors influencing this response are poorly understood. Here, we investigate the contribution of CD4 + T cells to B cell responses in human dengue infection. We identify a dominant peripheral PD-1 + T cell subset that accumulates in severe patients and could induce B cell differentiation via interleukin-21 (IL-21)-related pathway. Single-cell analyses reveal heterogeneity within PD-1 + cells, demonstrating the coexistence of subsets with \"helper\" (IL-21 + ) or \"cytotoxic\" characteristics. The IL-21 + subset displays a distinct clonotypic and transcriptomic signature compared to follicular helper T cells and persists as a memory in lymph nodes. Notably, we show that the IL-21 + subset seems to majorly drive the extrafollicular B cell responses in dengue. Our study establishes the peripheral IL-21 + subset as a potential determinant of the humoral response to dengue virus infection. These findings provide important insights into the T-cell-dependent regulation of humoral responses and can inform the design of effective dengue vaccines.","journal":"Cell Reports","year":2025,"id":515723,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":661094,"name":"Shilpa Sachan","orcid":null,"position":1,"is_corresponding":false},{"id":1334997,"name":"Jatin Ahuja","orcid":"0000-0002-3072-8735","position":2,"is_corresponding":false},{"id":1335240,"name":"Sureshkumar Venkadesan","orcid":null,"position":3,"is_corresponding":false},{"id":808675,"name":"Bhushan Nikam","orcid":null,"position":4,"is_corresponding":false},{"id":1334998,"name":"Vinod Kumar","orcid":"0000-0001-9089-4308","position":5,"is_corresponding":false},{"id":423967,"name":"Shweta Jain","orcid":"0000-0001-6297-0078","position":6,"is_corresponding":false},{"id":1334999,"name":"Bhanu Pratap Singh","orcid":"0000-0002-1757-9763","position":7,"is_corresponding":false},{"id":660266,"name":"Poonam Coshic","orcid":"0000-0002-4606-7417","position":8,"is_corresponding":false},{"id":1335000,"name":"Kapil Sikka","orcid":"0000-0002-3457-4518","position":9,"is_corresponding":false},{"id":1007531,"name":"Naveet Wig","orcid":"0000-0002-6603-601X","position":10,"is_corresponding":false},{"id":55670,"name":"Alessandro Sette","orcid":"0000-0001-7013-2250","position":11,"is_corresponding":false},{"id":103766,"name":"Daniela Weiskopf","orcid":"0000-0003-2968-7371","position":12,"is_corresponding":false},{"id":1380628,"name":"Debasisa Mohanty","orcid":"0000-0002-3374-0588","position":13,"is_corresponding":false},{"id":1007530,"name":"Manish Soneja","orcid":"0000-0002-8619-7929","position":14,"is_corresponding":false},{"id":554473,"name":"Nimesh Gupta","orcid":"0000-0001-9433-8448","position":15,"is_corresponding":false},{"id":660263,"name":"Asgar Ansari","orcid":"0000-0002-7073-1154","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-19T02:48:44.647022Z","pmid":"40073863","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}