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Modeling of recurrent networks with assemblies showed that a precise balance of excitation and inhibition is important to prevent not only excessive firing rates (\"runaway activity\") but also the stochastic occurrence of high pattern correlations (\"runaway correlations\"). Consistent with model predictions, runaway correlations emerged in pDp when synaptic balance was perturbed by optogenetic manipulations of feedback inhibition but not feedforward inhibition. Runaway correlations were driven by sparse subsets of strongly active neurons rather than by a general broadening of tuning curves. These results are consistent with balanced neuronal assemblies in pDp and reveal novel computational functions of inhibitory microcircuits in an autoassociative network.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39985769","pmcid":null,"openalex_id":"https://openalex.org/W4407778217","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"742576","title":"Connectivity, plasticity and function of an olfactory memory circuit"},{"funder_name":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","grant_id":"310030B_152833/1","title":null},{"funder_name":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","grant_id":"PCEFP3_202981","title":null},{"funder_name":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","grant_id":"31003A_172925/1","title":null},{"funder_name":"German Research Foundation","grant_id":"EXC 2067/1- 390729940","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Swiss National Science Foundation","grant_id":"172925","title":"Bottom-up and top-down neuronal computations in olfaction"},{"funder_name":"Swiss National Science Foundation","grant_id":"152833","title":"Computational functions of inhibitory neuronal circuits"},{"funder_name":"Swiss National Science Foundation","grant_id":"202981","title":"Understanding the role of inhibitory circuits in controlling plasticity and in implementing network-level objectives"},{"funder_name":"European Research Council","grant_id":"","title":null},{"funder_name":"Horizon 2020 Framework Programme","grant_id":"","title":null},{"funder_name":"European Molecular Biology Organization","grant_id":"","title":null},{"funder_name":"Human Frontier Science Program","grant_id":"","title":null},{"funder_name":"Novartis Foundation","grant_id":"","title":null},{"funder_name":"Novartis Foundation for Medical-Biological Research","grant_id":"","title":null},{"funder_name":"Horizon 2020","grant_id":"","title":null},{"funder_name":"Max Planck Society","grant_id":"","title":null}],"total_grants":17,"fwci":2.2599,"citation_percentile":0.84477183,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":3}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.1016/j.celrep.2025.115330","host_type":"journal"},{"url":"https://doi.org/10.1016/j.celrep.2025.115330","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124725001019?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124725001019?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39985769","host_type":"repository"},{"url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/148210","host_type":"repository"},{"url":"https://doaj.org/article/d4b2143730d74044b722b48d1858d103","host_type":"repository"},{"url":"https://hdl.handle.net/21.11116/0000-000F-37DE-A","host_type":""}],"fields_of_study":["Olfactory and Sensory Function Studies","Advanced Chemical Sensor Technologies","Neural dynamics and brain function","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Action Potentials","Animals","Interneurons","Memory","Models, Neurological","Nerve Net","Neurons","Smell","Synapses","Zebrafish","Optogenetics"],"keywords":["Neuroscience","Olfactory system","Computer science","Biology","Zebrafish","Optogenetics","Olfactory Cortex","Computational Neuroscience","Inhibitory Microcircuits","Ei Balance","Cp: Neuroscience","Neurons","QH301-705.5","Models, Neurological","Action Potentials","Memory","Interneurons","Animals","Biology (General)","Nerve Net"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T05:37:08.419084Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}