{"doi":"10.1016/j.celrep.2024.115088","title":"Contextual modulation emerges by integrating feedforward and feedback processing in mouse visual cortex","abstract":"Sensory systems use context to infer meaning. Accordingly, context profoundly influences neural responses to sensory stimuli. However, a cohesive understanding of the circuit mechanisms governing contextual effects across different stimulus conditions is still lacking. Here we present a unified circuit model of mouse visual cortex that accounts for the main standard forms of contextual modulation. This data-driven and biologically realistic circuit, including three primary inhibitory cell types, sheds light on how bottom-up, top-down, and recurrent inputs are integrated across retinotopic space to generate contextual effects in layer 2/3. We establish causal relationships between neural responses, geometrical features of the inputs, and the connectivity patterns. The model not only reveals how a single canonical cortical circuit differently modulates sensory response depending on context but also generates multiple testable predictions, offering insights that apply to broader neural circuitry.","journal":"Cell Reports","year":2024,"id":443912,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9388,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255258,"name":"Mario Dipoppa","orcid":"0000-0002-4454-4224","position":1,"is_corresponding":false},{"id":255257,"name":"Andreas Keller","orcid":"0000-0001-7997-6118","position":2,"is_corresponding":false},{"id":255259,"name":"Morgane Roth","orcid":"0000-0002-5714-6719","position":3,"is_corresponding":false},{"id":255262,"name":"Massimo Scanziani","orcid":"0000-0002-5331-9686","position":4,"is_corresponding":false},{"id":255261,"name":"Kenneth D. Miller","orcid":"0000-0002-1433-0647","position":5,"is_corresponding":false},{"id":987265,"name":"Serena Di Santo","orcid":"0000-0001-9646-4667","position":0,"is_corresponding":true}],"reference_count":111,"raw_metadata":null,"created_at":"2026-07-19T02:01:29.001453Z","pmid":"39709599","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}