{"doi":"10.1016/j.celrep.2024.115072","title":"Pathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis","abstract":"Neutrophils are vital for immunity against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), yet their heterogeneous nature suggests a complex role in TB pathogenesis. Here, we identify two distinct neutrophil populations based on CD101 expression, highlighting their divergent roles in TB. CD101-negative (CD101 −ve ) neutrophils, which resemble immature, pro-inflammatory granulocytes, exhibit reduced Mtb phagocytosis compared to their mature, CD101-positive (CD101 +ve ) counterparts. Our findings reveal that type I interferons (IFN-Is) suppress neutrophil Mtb uptake and drive the recruitment of CD101 −ve neutrophils to the lungs. Infiltration of these cells promotes Mtb extracellular persistence, exacerbates epithelial damage, and impairs surfactant production. Furthermore, we demonstrate that granulocyte colony-stimulating factor (G-CSF) and chemokine receptor CXCR2 are essential for the pulmonary accumulation of CD101 −ve neutrophils. Our study uncovers a pathogenic role for CD101 −ve neutrophils in TB and highlights the IFN-I-dependent recruitment of this functionally compromised immature neutrophil as a driver of TB immunopathogenesis.","journal":"Cell Reports","year":2024,"id":421229,"datarank":0.7472723420942368,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.22741195667427774,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.22741195667427774,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":29,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9488,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE203118"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":736331,"name":"Shreya Das","orcid":"0000-0003-2184-2488","position":1,"is_corresponding":false},{"id":884331,"name":"Tanvir Noor Nafiz","orcid":"0000-0003-2955-2880","position":2,"is_corresponding":false},{"id":470020,"name":"Elizabeth McDonough","orcid":"0000-0001-7524-8260","position":3,"is_corresponding":false},{"id":276630,"name":"Poornima Sankar","orcid":null,"position":4,"is_corresponding":false},{"id":1214066,"name":"L MISHRA","orcid":null,"position":5,"is_corresponding":false},{"id":1213394,"name":"Ximeng Zhang","orcid":"0000-0002-4593-3782","position":6,"is_corresponding":false},{"id":583587,"name":"Yi Cai","orcid":"0000-0002-1363-2328","position":7,"is_corresponding":false},{"id":336002,"name":"Selvakumar Subbian","orcid":"0000-0003-2021-8632","position":8,"is_corresponding":false},{"id":275821,"name":"Bibhuti B. Mishra","orcid":"0000-0002-7203-1653","position":9,"is_corresponding":false},{"id":736332,"name":"Mohd Saqib","orcid":"0000-0002-3800-0490","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-19T01:57:36.298171Z","pmid":"39693225","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}