{"doi":"10.1016/j.celrep.2024.115021","title":"Probiotics-sensing mechanism in neurons that initiates gut mitochondrial surveillance for pathogen defense","abstract":"Animals constantly face microbial challenges, and microbe-mediated infection protection is crucial for host survival. Identifying specific bacteria and their interactions with host intracellular surveillance systems is important but challenging. Here, we develop a \"probiotics\" screening system that identifies Escherichia coli mutants, such as ΔymcB , which protect hosts from Pseudomonas aeruginosa PA14 infection by activating the mitochondrial unfolded protein response (UPR mt ). Genetic screening reveals that MDSS-1, a neuronal transmembrane protein, is crucial for sensing ΔymcB and triggering intestinal UPR mt . MDSS-1 functions as a potential receptor in ASE neurons, detecting ΔymcB and transmitting signals through neuropeptides, GPCRs, Wnt signaling, and endopeptidase inhibitors to activate intestinal UPRmt and enhance protection. Constitutive activation of MDSS-1 in ASE neurons is sufficient to induce UPR mt and confer infection resistance. This study uncovers a neuron-intestine communication mechanism, where ASE neurons detect bacteria and modulate the intestinal mitochondrial surveillance system for host adaptation to pathogens.","journal":"Cell Reports","year":2024,"id":460478,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1247003,"name":"Panpan Chen","orcid":"0000-0003-0056-612X","position":1,"is_corresponding":false},{"id":1288638,"name":"Xubo Yang","orcid":"0000-0002-8791-5451","position":2,"is_corresponding":false},{"id":1057891,"name":"Fanrui Hao","orcid":null,"position":3,"is_corresponding":false},{"id":1057339,"name":"Guojing Tian","orcid":"0000-0001-5702-1142","position":4,"is_corresponding":false},{"id":268451,"name":"Zhao Shan","orcid":"0000-0001-5064-1023","position":5,"is_corresponding":false},{"id":1057341,"name":"Bin Qi","orcid":"0000-0003-2261-1550","position":6,"is_corresponding":false},{"id":626422,"name":"Huimin Liu","orcid":"0000-0002-2265-2961","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T02:04:07.925246Z","pmid":"39602305","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}