{"doi":"10.1016/j.celrep.2024.114991","title":"ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancer","abstract":"We previously described that the KDM5B histone H3 lysine 4 demethylase is an oncogene in estrogen-receptor-positive breast cancer. Here, we report that KDM5A is amplified and overexpressed in basal breast tumors, and KDM5 inhibition (KDM5i) suppresses the growth of KDM5-amplified breast cancer cell lines. Using CRISPR knockout screens in a basal breast cancer cell line with or without KDM5i, we found that deletion of the ZBTB7A transcription factor and core SAGA complex sensitizes cells to KDM5i, whereas deletion of RHO-GTPases leads to resistance. Chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq) revealed co-localization of ZBTB7A and KDM5A/B at promoters with high histone H3K4me3 and dependence of KDM5A chromatin binding on ZBTB7A. ZBTB7A knockout altered the transcriptional response to KDM5i at NF-κB targets and mitochondrion-related pathways. High expression of ZBTB7A in triple-negative breast cancer is significantly associated with poor response to neoadjuvant chemotherapy. Our work furthers the understanding of KDM5-mediated gene regulation and identifies mediators of sensitivity to KDM5i.","journal":"Cell Reports","year":2024,"id":441510,"datarank":0.3616220247631718,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.016234260814064875,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.016234260814064875,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":9,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE259252"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1037167,"name":"Marco Seehawer","orcid":"0000-0003-0440-6967","position":1,"is_corresponding":false},{"id":289452,"name":"Zheqi Li","orcid":"0000-0003-1213-640X","position":2,"is_corresponding":false},{"id":1255020,"name":"Andriana Patmanidis","orcid":null,"position":3,"is_corresponding":false},{"id":107610,"name":"Triet M. Bui","orcid":"0000-0002-1092-9820","position":4,"is_corresponding":false},{"id":259449,"name":"Pierre Foidart","orcid":"0000-0003-4198-271X","position":5,"is_corresponding":false},{"id":1208857,"name":"Jun Nishida","orcid":"0000-0001-5098-9361","position":6,"is_corresponding":false},{"id":351045,"name":"Clive S. D’Santos","orcid":"0000-0003-3425-7288","position":7,"is_corresponding":false},{"id":852772,"name":"Evangelia K. Papachristou","orcid":"0000-0002-5835-2055","position":8,"is_corresponding":false},{"id":664949,"name":"Malvina Papanastasiou","orcid":"0000-0003-3378-6612","position":9,"is_corresponding":false},{"id":866254,"name":"Andrew H. Reiter","orcid":"0000-0003-1406-4913","position":10,"is_corresponding":false},{"id":554209,"name":"Xintao Qiu","orcid":"0000-0002-8560-7017","position":11,"is_corresponding":false},{"id":1254571,"name":"Rong Li","orcid":"0000-0001-7266-0241","position":12,"is_corresponding":false},{"id":1018586,"name":"Yijia Jiang","orcid":"0000-0002-0239-6999","position":13,"is_corresponding":false},{"id":1045908,"name":"Huang Xiao-Yun","orcid":null,"position":14,"is_corresponding":false},{"id":228423,"name":"Anton Simeonov","orcid":"0000-0002-4523-9977","position":15,"is_corresponding":false},{"id":550316,"name":"Stephen C. Kales","orcid":"0000-0002-8702-5766","position":16,"is_corresponding":false},{"id":268294,"name":"Ganesha Rai","orcid":"0000-0001-9763-9641","position":17,"is_corresponding":false},{"id":331279,"name":"Madhu Lal‐Nag","orcid":"0000-0003-4924-6493","position":18,"is_corresponding":false},{"id":262007,"name":"Ajit Jadhav","orcid":"0000-0001-7955-1451","position":19,"is_corresponding":false},{"id":443,"name":"Myles Brown","orcid":"0000-0002-8213-1658","position":20,"is_corresponding":false},{"id":249329,"name":"Jason S. Carroll","orcid":"0000-0003-3643-0080","position":21,"is_corresponding":false},{"id":227618,"name":"Henry W. Long","orcid":"0000-0001-6849-6629","position":22,"is_corresponding":false},{"id":414226,"name":"Kornélia Polyák","orcid":"0000-0002-5964-0382","position":23,"is_corresponding":false},{"id":1045910,"name":"Benedetto Diciaccio","orcid":null,"position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T02:01:11.152920Z","pmid":"39570746","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}