{"doi":"10.1016/j.celrep.2024.114951","title":"Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection","abstract":"T helper (Th)17 cells mediate both protective anti-bacterial immune responses and autoimmune pathogenesis, but the distinct pathways regulating these Th17 responses remain unclear. Retinoid-related orphan receptor γ t (RORγt) is a master transcription factor that governs Th17 cell generation and effector functions. We found that a K256R mutation in RORγt impairs Th17-mediated experimental autoimmune encephalomyelitis (EAE) without affecting the clearance of Citrobacter rodentium . This indicates distinct RORγt roles in central nervous system pathogenesis versus gut-associated protective Th17 responses. Mechanically, RORγt/Runx1-dependent upregulation of galectin-3 (Lgals3) and chemokine receptor Ccr6 in CD4 + T cells is essential for EAE development but not for bacterial clearance. Moreover, Lgals3 is selectively required for recruiting macrophages to produce interleukin (IL)-1β, which in turn promotes Ccr6 expression on CD4 + T cells during EAE pathogenesis. Our findings highlight different RORγt-regulated Th17 pathways in autoimmunity and anti-bacterial immunity, with implications for therapies targeting Th17-mediated autoimmunity while preserving effective anti-bacterial responses.","journal":"Cell Reports","year":2024,"id":443602,"datarank":0.4089543045522505,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.07937061795181756,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.07937061795181756,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":7,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE211414","GSE211509"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1047476,"name":"Hongmin Wu","orcid":"0000-0002-0762-8322","position":1,"is_corresponding":false},{"id":1047477,"name":"Wencan Zhang","orcid":"0000-0002-8828-2000","position":2,"is_corresponding":false},{"id":1258218,"name":"Yunying Shi","orcid":"0000-0002-4544-5439","position":3,"is_corresponding":false},{"id":374505,"name":"Yousang Gwack","orcid":"0000-0002-2821-9245","position":4,"is_corresponding":false},{"id":271042,"name":"Hai‐Hui Xue","orcid":"0000-0002-9163-7669","position":5,"is_corresponding":false},{"id":378708,"name":"Zuoming Sun","orcid":"0000-0003-1896-6666","position":6,"is_corresponding":false},{"id":861624,"name":"Xiancai Zhong","orcid":"0000-0001-8312-4057","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T02:01:29.001453Z","pmid":"39504243","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}