{"doi":"10.1016/j.celrep.2024.114909","title":"General anesthesia activates a central anxiolytic center in the BNST","abstract":"Low doses of general anesthetics like ketamine and dexmedetomidine have anxiolytic properties independent of their sedative effects, but the underlying mechanisms remain unclear. We discovered a population of GABAergic neurons in the oval division of the bed nucleus of the stria terminalis that are activated by multiple anesthetics and the anxiolytic drug diazepam (ovBNST GA ). The majority of ovBNST GA neurons express neurotensin receptor 1 (Ntsr1) and form circuits with brain regions known to regulate anxiety and stress responses. Optogenetic activation of ovBNST GA or ovBNST Ntsr1 neurons significantly attenuated anxiety-like behaviors in both naive animals and mice with inflammatory pain, while inhibition of these cells elevated anxiety. Activation of these neurons decreased heart rate and increased heart rate variability, suggesting that they reduce anxiety by modulating autonomic responses. Our study identifies ovBNST GA /ovBNST Ntsr1 neurons as a common neural substrate mediating the anxiolytic effect of low-dose anesthetics and a potential therapeutic target for treating anxiety-related disorders.","journal":"Cell Reports","year":2024,"id":441364,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1179714,"name":"Camille G. Uldry Lavergne","orcid":null,"position":1,"is_corresponding":false},{"id":1179713,"name":"Seonmi Choi","orcid":null,"position":2,"is_corresponding":false},{"id":819779,"name":"Jae Hong Park","orcid":"0009-0004-3189-3830","position":3,"is_corresponding":false},{"id":1179387,"name":"Jiwoo Kim","orcid":"0009-0008-0898-8371","position":4,"is_corresponding":false},{"id":63853,"name":"Shengli Zhao","orcid":"0009-0007-9432-0070","position":5,"is_corresponding":false},{"id":1179715,"name":"Quinn Desimone","orcid":null,"position":6,"is_corresponding":false},{"id":1253859,"name":"Eva Lendaro","orcid":"0000-0001-9545-7633","position":7,"is_corresponding":false},{"id":1253860,"name":"Bin Chen","orcid":"0000-0002-9450-1986","position":8,"is_corresponding":false},{"id":820172,"name":"Bao-Xia Han","orcid":null,"position":9,"is_corresponding":false},{"id":284547,"name":"Fan Wang","orcid":"0000-0003-2988-0614","position":10,"is_corresponding":false},{"id":284610,"name":"Nitsan Goldstein","orcid":"0000-0003-0926-5366","position":11,"is_corresponding":false},{"id":772202,"name":"Dongye Lu","orcid":"0000-0002-3527-2482","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-19T02:01:06.281460Z","pmid":"39460938","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}