{"doi":"10.1016/j.celrep.2024.114906","title":"Paired C-type lectin receptors mediate specific recognition of divergent oomycete pathogens in C. elegans","abstract":"Innate immune responses can be triggered upon detection of pathogen- or damage-associated molecular patterns by host receptors that are often present on the surface of immune cells. While invertebrates like Caenorhabditis elegans lack professional immune cells, they still mount pathogen-specific responses. However, the identity of host receptors in the nematode remains poorly understood. Here, we show that C-type lectin receptors mediate species-specific recognition of divergent oomycetes in C. elegans. A CLEC-27/CLEC-35 pair is essential for recognition of the oomycete Myzocytiopsis humicola, while a CLEC-26/CLEC-36 pair is required for detection of Haptoglossa zoospora. Both clec pairs are transcriptionally regulated through a shared promoter by the conserved PRD-like homeodomain transcription factor CEH-37/OTX2 and act in sensory neurons and the anterior intestine to trigger a protective immune response in the epidermis. This system enables redundant tissue sensing of oomycete threats through canonical CLEC receptors and host defense via cross-tissue communication.","journal":"Cell Reports","year":2024,"id":429259,"datarank":0.40811638498229524,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.04843209406253958,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.04843209406253958,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":8,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.949,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE263858"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":703412,"name":"Manish Grover","orcid":"0000-0002-1625-7930","position":1,"is_corresponding":false},{"id":1231355,"name":"Franziska Trusch","orcid":"0000-0003-0608-202X","position":2,"is_corresponding":false},{"id":1048882,"name":"Christina Vagena-Pantoula","orcid":"0000-0002-3591-2267","position":3,"is_corresponding":false},{"id":715121,"name":"Domenica Ippolito","orcid":"0000-0002-8793-5065","position":4,"is_corresponding":false},{"id":308280,"name":"Michalis Barkoulas","orcid":"0000-0003-1974-7668","position":5,"is_corresponding":false},{"id":726912,"name":"Kenneth Liu","orcid":"0000-0002-4107-7296","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-19T01:59:06.668462Z","pmid":"39460939","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}