{"doi":"10.1016/j.celrep.2024.114876","title":"Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition","abstract":"Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide association studies (GWASs) have identified genetic variants predisposed to chronic pain. However, most of these variants lie within regulatory non-coding regions that have not been linked to spinal cord biology. Here, we take a multi-species approach to determine whether chronic pain variants impact the regulatory genomics of dorsal horn neurons. First, we generate a large rhesus macaque single-nucleus RNA sequencing (snRNA-seq) atlas and integrate it with available human and mouse datasets to produce a single unified, species-conserved atlas of neuron subtypes. Cellular-resolution spatial transcriptomics in mouse shows the precise laminar location of these neuron subtypes, consistent with our analysis of neuron-subtype-selective markers in macaque. Using this cross-species framework, we generate a mouse single-nucleus open chromatin atlas of regulatory elements that shows strong and selective relationships between the neuron-subtype-specific chromatin regions and variants from major chronic pain GWASs.","journal":"Cell Reports","year":2024,"id":424375,"datarank":0.5698394932732993,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.09951536088392678,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.09951536088392678,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":16,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE253954"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336248,"name":"Michael J. 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Kennedy Ng","orcid":"0000-0003-4612-7560","position":15,"is_corresponding":false},{"id":987989,"name":"Viola Chen","orcid":null,"position":16,"is_corresponding":false},{"id":78767,"name":"Ziheng Chen","orcid":"0000-0001-5709-8529","position":17,"is_corresponding":false},{"id":17177,"name":"Hansruedi Mathys","orcid":"0000-0003-0186-2115","position":18,"is_corresponding":false},{"id":635380,"name":"Richard P. Dum","orcid":null,"position":19,"is_corresponding":false},{"id":6269,"name":"David A. Lewis","orcid":"0000-0002-3225-6778","position":20,"is_corresponding":false},{"id":249986,"name":"Yawar J. Qadri","orcid":"0000-0003-2138-4018","position":21,"is_corresponding":false},{"id":257966,"name":"Theodore J. Price","orcid":"0000-0002-6971-6221","position":22,"is_corresponding":false},{"id":35838,"name":"Andreas Pfenning","orcid":"0000-0002-7390-5041","position":23,"is_corresponding":false},{"id":247861,"name":"Rebecca P. 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