{"doi":"10.1016/j.celrep.2024.114684","title":"SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner","abstract":"Immunity acquired by vaccination following infection, termed hybrid immunity, has been shown to confer enhanced protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by enhancing the breadth and potency of immune responses. Here, we assess Fc-mediated humoral profiles in hybrid immunity and their association with age and vaccine type. Participants are divided into three groups: infection only, vaccination only, and vaccination following infection (i.e., hybrid immunity). Using systems serology, we profile humoral immune responses against spikes and subdomains of SARS-CoV-2 variants. We find that hybrid immunity is characterized by superior Fc receptor binding and natural killer (NK) cell-, neutrophil-, and complement-activating antibodies, which is higher than what can be expected from the sum of the vaccination and infection. These differences between hybrid immunity and vaccine-induced immunity are more pronounced in aged adults, especially for immunoglobulin (Ig)G1, IgG2, and Fcγ receptor-binding antibodies. Our findings suggest that vaccination strategies that aim to mimic hybrid immunity should consider age as an important modifier.","journal":"Cell Reports","year":2024,"id":435710,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1038702,"name":"Arturo Abdelnour","orcid":null,"position":1,"is_corresponding":false},{"id":108375,"name":"Paulina Kapłonek","orcid":"0000-0001-9459-5946","position":2,"is_corresponding":false},{"id":265752,"name":"Rolando Herrero","orcid":"0000-0001-5448-3456","position":3,"is_corresponding":false},{"id":989736,"name":"Jessica Shih-Lu Lee","orcid":null,"position":4,"is_corresponding":false},{"id":1170386,"name":"Domenic R Barbati","orcid":null,"position":5,"is_corresponding":false},{"id":987502,"name":"Taras M. Chicz","orcid":"0000-0002-5204-2507","position":6,"is_corresponding":false},{"id":1243815,"name":"Kate S Levine","orcid":null,"position":7,"is_corresponding":false},{"id":1243816,"name":"Romain Clement Fantin","orcid":null,"position":8,"is_corresponding":false},{"id":1038240,"name":"Viviana Loría","orcid":"0000-0002-5679-7341","position":9,"is_corresponding":false},{"id":265750,"name":"Carolina Porras","orcid":"0000-0002-4592-3883","position":10,"is_corresponding":false},{"id":19320,"name":"Douglas A. Lauffenburger","orcid":"0000-0002-0050-989X","position":11,"is_corresponding":false},{"id":265760,"name":"Mitchell H. Gail","orcid":"0000-0002-3919-3263","position":12,"is_corresponding":false},{"id":948648,"name":"Amada Aparicio","orcid":null,"position":13,"is_corresponding":false},{"id":265756,"name":"Allan Hildesheim","orcid":"0000-0003-0257-2363","position":14,"is_corresponding":false},{"id":106757,"name":"Galit Alter","orcid":"0000-0002-7680-9215","position":15,"is_corresponding":false},{"id":302984,"name":"Ryan P. McNamara","orcid":"0000-0002-8866-3532","position":16,"is_corresponding":false},{"id":499372,"name":"Wonyeong Jung","orcid":"0009-0002-2789-0800","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-19T02:00:08.103086Z","pmid":"39213155","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}