{"doi":"10.1016/j.celrep.2024.114551","title":"Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer","abstract":"Ovarian cancer is characterized by early metastatic spread. This study demonstrates that carcinoma-associated mesenchymal stromal cells (CA-MSCs) enhance metastasis by increasing tumor cell heterogeneity through mitochondrial donation. CA-MSC mitochondrial donation preferentially occurs in ovarian cancer cells with low levels of mitochondria (\"mito poor\"). CA-MSC mitochondrial donation rescues the phenotype of mito poor cells, restoring their proliferative capacity, resistance to chemotherapy, and cellular respiration. Receipt of CA-MSC-derived mitochondria induces tumor cell transcriptional changes leading to the secretion of ANGPTL3, which enhances the proliferation of tumor cells without CA-MSC mitochondria, thus amplifying the impact of mitochondrial transfer. Donated CA-MSC mitochondrial DNA persisted in recipient tumor cells for at least 14 days. CA-MSC mitochondrial donation occurs in vivo, enhancing tumor cell heterogeneity and decreasing mouse survival. Collectively, this work identifies CA-MSC mitochondrial transfer as a critical mediator of ovarian cancer cell survival, heterogeneity, and metastasis and presents a unique therapeutic target in ovarian cancer.","journal":"Cell Reports","year":2024,"id":419272,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":768607,"name":"Catherine A. Pressimone","orcid":null,"position":1,"is_corresponding":false},{"id":1013861,"name":"Emma Dyer","orcid":"0000-0002-5818-3589","position":2,"is_corresponding":false},{"id":1209237,"name":"Roja Baruwal","orcid":null,"position":3,"is_corresponding":false},{"id":1208691,"name":"Geyon L. Garcia","orcid":"0000-0002-3918-2724","position":4,"is_corresponding":false},{"id":110052,"name":"Claudette M. St. Croix","orcid":"0000-0003-0794-4939","position":5,"is_corresponding":false},{"id":279286,"name":"Simon C. Watkins","orcid":"0000-0003-4092-1552","position":6,"is_corresponding":false},{"id":1209238,"name":"Michael Calderone","orcid":null,"position":7,"is_corresponding":false},{"id":1202750,"name":"Grace Gorecki","orcid":"0000-0002-4001-5528","position":8,"is_corresponding":false},{"id":893839,"name":"Zaineb Javed","orcid":"0000-0003-1336-2564","position":9,"is_corresponding":false},{"id":285618,"name":"Huda I. Atiya","orcid":"0000-0001-9850-102X","position":10,"is_corresponding":false},{"id":240809,"name":"Nadine Hempel","orcid":"0000-0002-5574-8783","position":11,"is_corresponding":false},{"id":110023,"name":"Alexander T. Pearson","orcid":"0000-0003-2801-7456","position":12,"is_corresponding":false},{"id":247748,"name":"Lan Coffman","orcid":"0000-0002-3753-1652","position":13,"is_corresponding":false},{"id":285622,"name":"Leonard Frisbie","orcid":"0000-0001-8996-4292","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:57:14.586331Z","pmid":"39067022","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}