{"doi":"10.1016/j.celrep.2024.114434","title":"CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus","abstract":"Development of type 2 diabetes mellitus (T2DM) is associated with low-grade chronic type 2 inflammation and disturbance of glucose homeostasis. Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the production of type 2 cytokines. Here, we demonstrate that CB 2 , a G-protein-coupled receptor (GPCR) and member of the endocannabinoid system, is expressed on both visceral adipose tissue (VAT)-derived murine and human ILC2s. Moreover, we utilize a combination of ex vivo and in vivo approaches to explore the functional and therapeutic impacts of CB 2 engagement on VAT ILC2s in a T2DM model. Our results show that CB 2 stimulation of ILC2s protects against insulin-resistance onset, ameliorates glucose tolerance, and reverses established insulin resistance. Our mechanistic studies reveal that the therapeutic effects of CB 2 are mediated through activation of the AKT, ERK1/2, and CREB pathways on ILC2s. The results reveal that the CB 2 agonist can serve as a candidate for the prevention and treatment of T2DM.","journal":"Cell Reports","year":2024,"id":427404,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":419053,"name":"Shi Yan","orcid":null,"position":1,"is_corresponding":false},{"id":1228107,"name":"Mohammad H. Kazemi","orcid":null,"position":2,"is_corresponding":false},{"id":225647,"name":"Xin Li","orcid":"0000-0001-6860-3375","position":3,"is_corresponding":false},{"id":1062383,"name":"Amitis Akbari","orcid":null,"position":4,"is_corresponding":false},{"id":1210040,"name":"Kei Sakano","orcid":"0000-0002-0504-1691","position":5,"is_corresponding":false},{"id":1210038,"name":"Yoshihiro Sakano","orcid":"0000-0002-7633-6657","position":6,"is_corresponding":false},{"id":241528,"name":"Benjamin P. Hurrell","orcid":"0000-0001-7753-2927","position":7,"is_corresponding":false},{"id":660358,"name":"Christine Quach","orcid":"0000-0003-4802-8013","position":8,"is_corresponding":false},{"id":241527,"name":"Pedram Shafiei-Jahani","orcid":"0000-0003-1768-0770","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T01:58:47.805440Z","pmid":"38963763","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}