{"doi":"10.1016/j.celrep.2024.114426","title":"Splenic marginal zone B cells restrict Mycobacterium tuberculosis infection by shaping the cytokine pattern and cell-mediated immunity","abstract":"Understanding the role of B cells in tuberculosis (TB) is crucial for developing new TB vaccines. However, the changes in B cell immune landscapes during TB and their functional implications remain incompletely explored. Using high-dimensional flow cytometry to map the immune landscape in response to Mycobacterium tuberculosis (Mtb) infection, our results show an accumulation of marginal zone B (MZB) cells and other unconventional B cell subsets in the lungs and spleen, shaping an unconventional B cell landscape. These MZB cells exhibit activated and memory-like phenotypes, distinguishing their functional profiles from those of conventional B cells. Notably, functional studies show that MZB cells produce multiple cytokines and contribute to systemic protection against TB by shaping cytokine patterns and cell-mediated immunity. These changes in the immune landscape are reversible upon successful TB chemotherapy. Our study suggests that, beyond antibody production, targeting the regulatory function of B cells may be a valuable strategy for TB vaccine development.","journal":"Cell Reports","year":2024,"id":427401,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":768080,"name":"Myo Minn Oo","orcid":"0000-0003-4089-016X","position":1,"is_corresponding":false},{"id":1228099,"name":"Jih Hou Peh","orcid":null,"position":2,"is_corresponding":false},{"id":1228100,"name":"Benjamin Chaik Meng Yeo","orcid":null,"position":3,"is_corresponding":false},{"id":696915,"name":"Ariel A. Aptekmann","orcid":"0000-0001-8822-4372","position":4,"is_corresponding":false},{"id":227133,"name":"Bernett Lee","orcid":"0000-0002-2709-1972","position":5,"is_corresponding":false},{"id":1228101,"name":"Joe J. J. Liu","orcid":null,"position":6,"is_corresponding":false},{"id":1032666,"name":"Wen-Shan Tsao","orcid":null,"position":7,"is_corresponding":false},{"id":270341,"name":"Thomas Dick","orcid":"0000-0002-9604-9452","position":8,"is_corresponding":false},{"id":217936,"name":"Katja Fink","orcid":"0000-0002-3571-0390","position":9,"is_corresponding":false},{"id":270338,"name":"Martin Gengenbacher","orcid":"0000-0002-0208-5920","position":10,"is_corresponding":false},{"id":1104538,"name":"Chen-Yu Tsai","orcid":null,"position":0,"is_corresponding":true}],"reference_count":142,"raw_metadata":null,"created_at":"2026-07-19T01:58:47.805440Z","pmid":"38959109","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}